Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria

Metabolic reprogramming (MR) influences progression of chronic myeloid leukaemia (CML) to blast crisis (BC), but metabolic programs may change transiently in a second dimension (metabolic plasticity, MP), driven by environments as hypoxia, affecting cytotoxic potency (CPot) of drugs targeting mitoch...

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Detalles Bibliográficos
Autores principales: Salaverry, Luciana S., Lombardo, Tomás, Cabral-Lorenzo, María C., Gil-Folgar, Martin L., Rey-Roldán, Estela B., Kornblihtt, Laura I., Blanco, Guillermo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270554/
https://www.ncbi.nlm.nih.gov/pubmed/35802257
http://dx.doi.org/10.1007/s12672-022-00524-y

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