Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study

The association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype, and oxidative stress status of migraineurs with PFO on 100 mg/day aspirin, before and 6 months after PFO closure. Data show that, before PFO clos...

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Autores principales: Trabattoni, Daniela, Brambilla, Marta, Canzano, Paola, Becchetti, Alessia, Teruzzi, Giovanni, Porro, Benedetta, Fiorelli, Susanna, Muratori, Manuela, Tedesco, Calogero C., Veglia, Fabrizio, Montorsi, Piero, Bartorelli, Antonio L., Tremoli, Elena, Camera, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270571/
https://www.ncbi.nlm.nih.gov/pubmed/35818509
http://dx.doi.org/10.1016/j.jacbts.2022.02.002
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author Trabattoni, Daniela
Brambilla, Marta
Canzano, Paola
Becchetti, Alessia
Teruzzi, Giovanni
Porro, Benedetta
Fiorelli, Susanna
Muratori, Manuela
Tedesco, Calogero C.
Veglia, Fabrizio
Montorsi, Piero
Bartorelli, Antonio L.
Tremoli, Elena
Camera, Marina
author_facet Trabattoni, Daniela
Brambilla, Marta
Canzano, Paola
Becchetti, Alessia
Teruzzi, Giovanni
Porro, Benedetta
Fiorelli, Susanna
Muratori, Manuela
Tedesco, Calogero C.
Veglia, Fabrizio
Montorsi, Piero
Bartorelli, Antonio L.
Tremoli, Elena
Camera, Marina
author_sort Trabattoni, Daniela
collection PubMed
description The association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype, and oxidative stress status of migraineurs with PFO on 100 mg/day aspirin, before and 6 months after PFO closure. Data show that, before PFO closure, expression of the classical platelet activation markers is comparable in patients and aspirin-treated healthy subjects. Conversely, MHA-PFO patients display an increased prothrombotic phenotype (higher tissue factor(pos) platelets and microvesicles and thrombin-generation potential), sustained by an altered oxidative stress status. This phenotype, which is more controlled by P2Y(12)-blockade than by aspirin, reverted after PFO closure together with a complete migraine remission. (pLatelEts And MigRaine iN patEnt foRamen Ovale [LEARNER]; NCT03521193)
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spelling pubmed-92705712022-07-10 Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study Trabattoni, Daniela Brambilla, Marta Canzano, Paola Becchetti, Alessia Teruzzi, Giovanni Porro, Benedetta Fiorelli, Susanna Muratori, Manuela Tedesco, Calogero C. Veglia, Fabrizio Montorsi, Piero Bartorelli, Antonio L. Tremoli, Elena Camera, Marina JACC Basic Transl Sci Clinical Research The association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype, and oxidative stress status of migraineurs with PFO on 100 mg/day aspirin, before and 6 months after PFO closure. Data show that, before PFO closure, expression of the classical platelet activation markers is comparable in patients and aspirin-treated healthy subjects. Conversely, MHA-PFO patients display an increased prothrombotic phenotype (higher tissue factor(pos) platelets and microvesicles and thrombin-generation potential), sustained by an altered oxidative stress status. This phenotype, which is more controlled by P2Y(12)-blockade than by aspirin, reverted after PFO closure together with a complete migraine remission. (pLatelEts And MigRaine iN patEnt foRamen Ovale [LEARNER]; NCT03521193) Elsevier 2022-04-13 /pmc/articles/PMC9270571/ /pubmed/35818509 http://dx.doi.org/10.1016/j.jacbts.2022.02.002 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Trabattoni, Daniela
Brambilla, Marta
Canzano, Paola
Becchetti, Alessia
Teruzzi, Giovanni
Porro, Benedetta
Fiorelli, Susanna
Muratori, Manuela
Tedesco, Calogero C.
Veglia, Fabrizio
Montorsi, Piero
Bartorelli, Antonio L.
Tremoli, Elena
Camera, Marina
Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title_full Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title_fullStr Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title_full_unstemmed Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title_short Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study
title_sort migraine in patients undergoing pfo closure: characterization of a platelet-associated pathophysiological mechanism: the learner study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270571/
https://www.ncbi.nlm.nih.gov/pubmed/35818509
http://dx.doi.org/10.1016/j.jacbts.2022.02.002
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