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Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)

BACKGROUND: Korean Red Ginseng (KRG) extract has been shown to have beneficial effects in patients with atherosclerosis, suggesting that KRG extract may be effective in preventing subsequent ischemic stroke in patients with severe atherosclerosis. METHODS: This double-blind, placebo-controlled trial...

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Autores principales: Kwon, Boseong, Song, Yunsun, Kim, Joong-Goo, Lee, Dongwhane, Lee, Sang-hun, Cho, Young-Keol, Kim, Jong S., Suh, Dae Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270648/
https://www.ncbi.nlm.nih.gov/pubmed/35818424
http://dx.doi.org/10.1016/j.jgr.2021.11.002
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author Kwon, Boseong
Song, Yunsun
Kim, Joong-Goo
Lee, Dongwhane
Lee, Sang-hun
Cho, Young-Keol
Kim, Jong S.
Suh, Dae Chul
author_facet Kwon, Boseong
Song, Yunsun
Kim, Joong-Goo
Lee, Dongwhane
Lee, Sang-hun
Cho, Young-Keol
Kim, Jong S.
Suh, Dae Chul
author_sort Kwon, Boseong
collection PubMed
description BACKGROUND: Korean Red Ginseng (KRG) extract has been shown to have beneficial effects in patients with atherosclerosis, suggesting that KRG extract may be effective in preventing subsequent ischemic stroke in patients with severe atherosclerosis. METHODS: This double-blind, placebo-controlled trial randomized patients with severe atherosclerosis in major intracranial arteries or extracranial carotid artery, to ginseng group and placebo group. They were given two 500-mg KRG tablets or identical placebo tablets twice daily for 12 months according to randomization. The primary endpoint was the composite of cerebral ischemic stroke and transient ischemic attack during 12 months after randomization. The secondary endpoints were change in volumetric blood flow of the intracranial vessels and the incidence of newly developed asymptomatic ischemic lesions. Any adverse events were monitored. RESULTS: Fifty-eight patients were randomized from June 2016 to June 2017, 29 to ginseng and 29 to placebo, and 52 (28 and 24, respectively) completed the study. One patient in the placebo group, but none in the ginseng group, experienced ischemic symptoms (p = 0.46). Changes in volumetric blood flow and the presence of ischemic brain lesions did not differ significantly in the two groups, and none of these patients experienced adverse drug reactions. CONCLUSION: Ginseng was well tolerated by patients with severe atherosclerosis, with these patients showing good compliance with ginseng dosing. Ginseng did not show significant effects compared with placebo, although none of the ginseng-treated patients experienced ischemic events. Long-term studies in larger patient populations are required to test the effect of ginseng.
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spelling pubmed-92706482022-07-10 Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial) Kwon, Boseong Song, Yunsun Kim, Joong-Goo Lee, Dongwhane Lee, Sang-hun Cho, Young-Keol Kim, Jong S. Suh, Dae Chul J Ginseng Res Research Article BACKGROUND: Korean Red Ginseng (KRG) extract has been shown to have beneficial effects in patients with atherosclerosis, suggesting that KRG extract may be effective in preventing subsequent ischemic stroke in patients with severe atherosclerosis. METHODS: This double-blind, placebo-controlled trial randomized patients with severe atherosclerosis in major intracranial arteries or extracranial carotid artery, to ginseng group and placebo group. They were given two 500-mg KRG tablets or identical placebo tablets twice daily for 12 months according to randomization. The primary endpoint was the composite of cerebral ischemic stroke and transient ischemic attack during 12 months after randomization. The secondary endpoints were change in volumetric blood flow of the intracranial vessels and the incidence of newly developed asymptomatic ischemic lesions. Any adverse events were monitored. RESULTS: Fifty-eight patients were randomized from June 2016 to June 2017, 29 to ginseng and 29 to placebo, and 52 (28 and 24, respectively) completed the study. One patient in the placebo group, but none in the ginseng group, experienced ischemic symptoms (p = 0.46). Changes in volumetric blood flow and the presence of ischemic brain lesions did not differ significantly in the two groups, and none of these patients experienced adverse drug reactions. CONCLUSION: Ginseng was well tolerated by patients with severe atherosclerosis, with these patients showing good compliance with ginseng dosing. Ginseng did not show significant effects compared with placebo, although none of the ginseng-treated patients experienced ischemic events. Long-term studies in larger patient populations are required to test the effect of ginseng. Elsevier 2022-07 2021-11-11 /pmc/articles/PMC9270648/ /pubmed/35818424 http://dx.doi.org/10.1016/j.jgr.2021.11.002 Text en © 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kwon, Boseong
Song, Yunsun
Kim, Joong-Goo
Lee, Dongwhane
Lee, Sang-hun
Cho, Young-Keol
Kim, Jong S.
Suh, Dae Chul
Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title_full Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title_fullStr Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title_full_unstemmed Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title_short Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
title_sort preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: a randomized controlled trial (pegasus trial)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270648/
https://www.ncbi.nlm.nih.gov/pubmed/35818424
http://dx.doi.org/10.1016/j.jgr.2021.11.002
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