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Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence
Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270740/ https://www.ncbi.nlm.nih.gov/pubmed/35804440 http://dx.doi.org/10.1186/s13567-022-01073-6 |
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author | Eloiflin, Roger-Junior Grau-Roma, Llorenç Python, Sylvie Mehinagic, Kemal Godel, Aurélie Libeau, Geneviève Summerfield, Artur Bataille, Arnaud García-Nicolás, Obdulio |
author_facet | Eloiflin, Roger-Junior Grau-Roma, Llorenç Python, Sylvie Mehinagic, Kemal Godel, Aurélie Libeau, Geneviève Summerfield, Artur Bataille, Arnaud García-Nicolás, Obdulio |
author_sort | Eloiflin, Roger-Junior |
collection | PubMed |
description | Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain. A previous study highlighted the difference in virulence between two strains of PPRV used to infect Saanen goats. For this breed, PPRV Morocco 2008 strain (MA08) was highly virulent while PPRV Côte d’Ivoire 1989 (IC89) strain induced mild disease. Experimental studies generally based on healthy and young animals do not permit exploration of the natural variability of the host susceptibility to PPRV. Therefore, building on the previous study on Saanen goats, the current study focussed on this breed of goat and used commercially available animals with an unknown history of infection with other pathogens. Results confirmed the previous disease pattern for PPRV IC89 and MA08 strains. Viral RNA detection, macroscopic and histological lesions were stronger for the highly virulent MA08 strain. We show here for the first time that viral RNA can be detected in the tissues of vaccinated animals. Viral RNA was also detected for the first time in serum samples, which is in agreement with the role of circulating immune cells in transporting the virus into host target organs. Thus, this study provides insight into the pathogenesis of strains of different virulence of PPRV and will help to better understand the onset of the disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-022-01073-6. |
format | Online Article Text |
id | pubmed-9270740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92707402022-07-10 Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence Eloiflin, Roger-Junior Grau-Roma, Llorenç Python, Sylvie Mehinagic, Kemal Godel, Aurélie Libeau, Geneviève Summerfield, Artur Bataille, Arnaud García-Nicolás, Obdulio Vet Res Research Article Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain. A previous study highlighted the difference in virulence between two strains of PPRV used to infect Saanen goats. For this breed, PPRV Morocco 2008 strain (MA08) was highly virulent while PPRV Côte d’Ivoire 1989 (IC89) strain induced mild disease. Experimental studies generally based on healthy and young animals do not permit exploration of the natural variability of the host susceptibility to PPRV. Therefore, building on the previous study on Saanen goats, the current study focussed on this breed of goat and used commercially available animals with an unknown history of infection with other pathogens. Results confirmed the previous disease pattern for PPRV IC89 and MA08 strains. Viral RNA detection, macroscopic and histological lesions were stronger for the highly virulent MA08 strain. We show here for the first time that viral RNA can be detected in the tissues of vaccinated animals. Viral RNA was also detected for the first time in serum samples, which is in agreement with the role of circulating immune cells in transporting the virus into host target organs. Thus, this study provides insight into the pathogenesis of strains of different virulence of PPRV and will help to better understand the onset of the disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-022-01073-6. BioMed Central 2022-07-08 2022 /pmc/articles/PMC9270740/ /pubmed/35804440 http://dx.doi.org/10.1186/s13567-022-01073-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Eloiflin, Roger-Junior Grau-Roma, Llorenç Python, Sylvie Mehinagic, Kemal Godel, Aurélie Libeau, Geneviève Summerfield, Artur Bataille, Arnaud García-Nicolás, Obdulio Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title | Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title_full | Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title_fullStr | Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title_full_unstemmed | Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title_short | Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
title_sort | comparative pathogenesis of peste des petits ruminants virus strains of difference virulence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270740/ https://www.ncbi.nlm.nih.gov/pubmed/35804440 http://dx.doi.org/10.1186/s13567-022-01073-6 |
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