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Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases

BACKGROUND: The Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in humans and animals. Deep pyoderma caused by these bacteria in dogs has been previously reported. This case series aims to describe contrasting treatment responses in Bcc-related deep pyoderma in two dogs, a male and a...

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Autores principales: Shinomiya, Yuki, Takagaki, Shingo, Kawakami, Yoshiki, Motegi, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of Veterinary Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270938/
https://www.ncbi.nlm.nih.gov/pubmed/35821768
http://dx.doi.org/10.5455/OVJ.2022.v12.i3.1
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author Shinomiya, Yuki
Takagaki, Shingo
Kawakami, Yoshiki
Motegi, Tomoki
author_facet Shinomiya, Yuki
Takagaki, Shingo
Kawakami, Yoshiki
Motegi, Tomoki
author_sort Shinomiya, Yuki
collection PubMed
description BACKGROUND: The Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in humans and animals. Deep pyoderma caused by these bacteria in dogs has been previously reported. This case series aims to describe contrasting treatment responses in Bcc-related deep pyoderma in two dogs, a male and a female. CASE DESCRIPTION: Both patients had a history of immune-mediated polyarthritis (IMPA) managed with oral ciclosporin and prednisolone. Their skin lesions were multifocal, irregular, erythematous to hemorrhagic, alopecic papules, plaques, and nodules, with extensive crusting, draining tracts, and ulceration. Cytological findings revealed a marked inflammatory response consisting of non-degenerative and degenerative neutrophils and macrophages, with moderate to abundant intracellular and extracellular Bcc. Ciclosporin and prednisolone were stopped in case 2 after diagnosis. However, it was challenging to stop the regimen in case 1 because of the recurrence of IMPA and the onset of iatrogenic hypoadrenocorticism. Case 1 did not achieve remission for approximately 66 weeks even with seven protocols because of multiple relapses, whereas it took only 3 weeks to achieve remission in case 2 while using one drug. CONCLUSION: For deep pyoderma with extensive lesions in immunosuppressed patients, one should consider infection with Bcc. Therefore, immunosuppressants should promptly be reduced in such patients, and then, intensive antimicrobial therapy may achieve remission.
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spelling pubmed-92709382022-07-11 Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases Shinomiya, Yuki Takagaki, Shingo Kawakami, Yoshiki Motegi, Tomoki Open Vet J Case Report BACKGROUND: The Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in humans and animals. Deep pyoderma caused by these bacteria in dogs has been previously reported. This case series aims to describe contrasting treatment responses in Bcc-related deep pyoderma in two dogs, a male and a female. CASE DESCRIPTION: Both patients had a history of immune-mediated polyarthritis (IMPA) managed with oral ciclosporin and prednisolone. Their skin lesions were multifocal, irregular, erythematous to hemorrhagic, alopecic papules, plaques, and nodules, with extensive crusting, draining tracts, and ulceration. Cytological findings revealed a marked inflammatory response consisting of non-degenerative and degenerative neutrophils and macrophages, with moderate to abundant intracellular and extracellular Bcc. Ciclosporin and prednisolone were stopped in case 2 after diagnosis. However, it was challenging to stop the regimen in case 1 because of the recurrence of IMPA and the onset of iatrogenic hypoadrenocorticism. Case 1 did not achieve remission for approximately 66 weeks even with seven protocols because of multiple relapses, whereas it took only 3 weeks to achieve remission in case 2 while using one drug. CONCLUSION: For deep pyoderma with extensive lesions in immunosuppressed patients, one should consider infection with Bcc. Therefore, immunosuppressants should promptly be reduced in such patients, and then, intensive antimicrobial therapy may achieve remission. Faculty of Veterinary Medicine 2022 2022-05-10 /pmc/articles/PMC9270938/ /pubmed/35821768 http://dx.doi.org/10.5455/OVJ.2022.v12.i3.1 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shinomiya, Yuki
Takagaki, Shingo
Kawakami, Yoshiki
Motegi, Tomoki
Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title_full Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title_fullStr Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title_full_unstemmed Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title_short Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases
title_sort contrasting treatment responses by burkholderia cepacia complex-related deep pyoderma: a series of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270938/
https://www.ncbi.nlm.nih.gov/pubmed/35821768
http://dx.doi.org/10.5455/OVJ.2022.v12.i3.1
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