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Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis

OBJECTIVES: To investigate how age, malnutrition, and the level of plasma cortisol and phosphate in patients with Parkinson's disease (PD) at time of diagnosis are associated with body composition and handgrip strength in males and females compared to controls. Materials & Methods. This cro...

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Autores principales: Håglin, Lena, Törnkvist, Birgitta, Edström, Mona, Håglin, Sofia, Bäckman, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271002/
https://www.ncbi.nlm.nih.gov/pubmed/35818405
http://dx.doi.org/10.1155/2022/1516807
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author Håglin, Lena
Törnkvist, Birgitta
Edström, Mona
Håglin, Sofia
Bäckman, Lennart
author_facet Håglin, Lena
Törnkvist, Birgitta
Edström, Mona
Håglin, Sofia
Bäckman, Lennart
author_sort Håglin, Lena
collection PubMed
description OBJECTIVES: To investigate how age, malnutrition, and the level of plasma cortisol and phosphate in patients with Parkinson's disease (PD) at time of diagnosis are associated with body composition and handgrip strength in males and females compared to controls. Materials & Methods. This cross-sectional study includes baseline data from a cohort of newly diagnosed patients with Parkinson's disease (N = 75; M/F = 41/34) in the New Parkinsonism in Umeå study (NYPUM). Body Impedance (BIS), handgrip strength (HGS) assessments, and evaluation of risk for malnutrition (Mini Nutritional Assessment (MNA) score) and cognitive performance (Mini-Mental State Examination (MMSE)) were performed at time of PD diagnosis. RESULTS: Low fat-free mass index (FFMI), MNA score, and a high Unified Parkinson's Disease Rating Scale (UPDRS-total and UPDRS-III) were associated with high daytime levels of P-cortisol in total PD population but not in controls. Partial correlations reveal that high fat mass percent (FM (%)) and low FFMI were associated with older age in males with PD but not females with PD. Risk of malnutrition was associated with P-cortisol in males but not in females with PD (r = −0.511, P=0.001, and n = 41 and r = −0.055, P=0.759, and n = 34, respectively). Multiple linear regressions show that an interaction between P-cortisol and P-phosphate, older age, and high UPDRS-III score were associated with HGS in total patient population and males but not females. CONCLUSIONS: Age- and disease-associated risk factors that decrease muscle mass and HGS and increase FM (%) in patients with PD differ between males and females by an association with levels of cortisol and phosphate.
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spelling pubmed-92710022022-07-10 Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis Håglin, Lena Törnkvist, Birgitta Edström, Mona Håglin, Sofia Bäckman, Lennart Parkinsons Dis Research Article OBJECTIVES: To investigate how age, malnutrition, and the level of plasma cortisol and phosphate in patients with Parkinson's disease (PD) at time of diagnosis are associated with body composition and handgrip strength in males and females compared to controls. Materials & Methods. This cross-sectional study includes baseline data from a cohort of newly diagnosed patients with Parkinson's disease (N = 75; M/F = 41/34) in the New Parkinsonism in Umeå study (NYPUM). Body Impedance (BIS), handgrip strength (HGS) assessments, and evaluation of risk for malnutrition (Mini Nutritional Assessment (MNA) score) and cognitive performance (Mini-Mental State Examination (MMSE)) were performed at time of PD diagnosis. RESULTS: Low fat-free mass index (FFMI), MNA score, and a high Unified Parkinson's Disease Rating Scale (UPDRS-total and UPDRS-III) were associated with high daytime levels of P-cortisol in total PD population but not in controls. Partial correlations reveal that high fat mass percent (FM (%)) and low FFMI were associated with older age in males with PD but not females with PD. Risk of malnutrition was associated with P-cortisol in males but not in females with PD (r = −0.511, P=0.001, and n = 41 and r = −0.055, P=0.759, and n = 34, respectively). Multiple linear regressions show that an interaction between P-cortisol and P-phosphate, older age, and high UPDRS-III score were associated with HGS in total patient population and males but not females. CONCLUSIONS: Age- and disease-associated risk factors that decrease muscle mass and HGS and increase FM (%) in patients with PD differ between males and females by an association with levels of cortisol and phosphate. Hindawi 2022-07-02 /pmc/articles/PMC9271002/ /pubmed/35818405 http://dx.doi.org/10.1155/2022/1516807 Text en Copyright © 2022 Lena Håglin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Håglin, Lena
Törnkvist, Birgitta
Edström, Mona
Håglin, Sofia
Bäckman, Lennart
Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title_full Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title_fullStr Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title_full_unstemmed Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title_short Handgrip Strength and Anthropometry in Parkinson's Disease at Diagnosis
title_sort handgrip strength and anthropometry in parkinson's disease at diagnosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271002/
https://www.ncbi.nlm.nih.gov/pubmed/35818405
http://dx.doi.org/10.1155/2022/1516807
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