Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

Robust rhythms of abundances and phosphorylation profiles of PERIOD proteins were thought be the master rhythms that drive mammalian circadian clock functions. PER stability was proposed to be a major determinant of period length. In mammals, CK1 forms stable complexes with PER. Here we identify the...

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Detalles Bibliográficos
Autores principales: An, Yang, Yuan, Baoshi, Xie, Pancheng, Gu, Yue, Liu, Zhiwei, Wang, Tao, Li, Zhihao, Xu, Ying, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271041/
https://www.ncbi.nlm.nih.gov/pubmed/35810166
http://dx.doi.org/10.1038/s41467-022-31715-4

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