NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice

Overstimulation of N-methyl-d-aspartate receptors (NMDARs) is the leading cause of brain excitotoxicity and often contributes to neurodegenerative diseases such as Alzheimer’s Disease (AD), the most common form of dementia. This study aimed to evaluate a new NMDA receptor antagonist (UB-ALT-EV) and...

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Detalles Bibliográficos
Autores principales: Companys-Alemany, Júlia, Turcu, Andreea L., Schneider, Marion, Müller, Christa E., Vázquez, Santiago, Griñán-Ferré, Christian, Pallàs, Mercè
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271115/
https://www.ncbi.nlm.nih.gov/pubmed/35810220
http://dx.doi.org/10.1007/s00018-022-04438-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271115/
https://www.ncbi.nlm.nih.gov/pubmed/35810220
http://dx.doi.org/10.1007/s00018-022-04438-4

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