Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia

DNA methyltransferase inhibitors (DNMTis) reexpress hypermethylated genes in cancers and leukemias and also activate endogenous retroviruses (ERVs), leading to interferon (IFN) signaling, in a process known as viral mimicry. In the present study we show that in the subset of acute myeloid leukemias...

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Detalles Bibliográficos
Autores principales: Kogan, Aksinija A., Topper, Michael J., Dellomo, Anna J., Stojanovic, Lora, McLaughlin, Lena J., Creed, T. Michael, Eberly, Christian L., Kingsbury, Tami J., Baer, Maria R., Kessler, Michael D., Baylin, Stephen B., Rassool, Feyruz V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271208/
https://www.ncbi.nlm.nih.gov/pubmed/35759659
http://dx.doi.org/10.1073/pnas.2123227119

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