Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

Hassall’s corpuscles (HCs) are composed of cornifying, terminally differentiated medullary thymic epithelial cells (mTECs) that are developed under the control of Aire. Here, we demonstrated that HC-mTECs show features of cellular senescence and produce inflammatory cytokines and chemokines includin...

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Detalles Bibliográficos
Autores principales: Wang, Jianwei, Sekai, Miho, Matsui, Takeshi, Fujii, Yosuke, Matsumoto, Mitsuru, Takeuchi, Osamu, Minato, Nagahiro, Hamazaki, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271218/
https://www.ncbi.nlm.nih.gov/pubmed/30534943
http://dx.doi.org/10.1093/intimm/dxy073

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