Cargando…

Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence

PURPOSE: Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments detected by neuroimaging in methamphetamine abstainers (MAs) during short-term a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gong, Mingqiang, Shen, Yunxia, Liang, Wenbin, Zhang, Zhen, He, Chunxue, Lou, Mingwu, Xu, ZiYu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271316/
https://www.ncbi.nlm.nih.gov/pubmed/35821766
http://dx.doi.org/10.2147/IJGM.S369571
_version_ 1784744655969058816
author Gong, Mingqiang
Shen, Yunxia
Liang, Wenbin
Zhang, Zhen
He, Chunxue
Lou, Mingwu
Xu, ZiYu
author_facet Gong, Mingqiang
Shen, Yunxia
Liang, Wenbin
Zhang, Zhen
He, Chunxue
Lou, Mingwu
Xu, ZiYu
author_sort Gong, Mingqiang
collection PubMed
description PURPOSE: Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments detected by neuroimaging in methamphetamine abstainers (MAs) during short-term abstinence. This study aimed to investigate effective connectivity, resting-state networks, and internetwork functional connectivity in MA brains to improve clinical treatment. METHODS: Twenty MAs and 27 age- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging. The amplitude of low-frequency fluctuations and Granger causality were analyzed to investigate disrupted brain regions and effective connectivity, respectively. Independent component analysis and functional network connectivity were used to identify resting-state networks and internetwork functional connectivity, respectively. RESULTS: Compared with healthy controls, MAs demonstrated abnormal amplitudes of low-frequency fluctuations in the bilateral precuneus, left posterior cingulate cortex (PCC), left middle frontal gyrus (MFG), left superior parietal lobule, left supplementary motor area (SMA), and left inferior parietal lobule (IPL). Moreover, MAs showed decreased effective connectivity from the left PCC to the left precuneus, increased effective connectivity from the left precuneus to the left MFG and from the right precuneus to the left SMA, and altered functional connectivity within the default mode network (DMN), frontoparietal network, sensorimotor network, ventral attention network, cerebellar network, and visual network. Importantly, hyperconnectivity between the DMN and ventral attention network and hypoconnectivity between the DMN and cerebellar network as well as the DMN and frontoparietal network were demonstrated in MAs. CONCLUSION: Our study implies that in short-term methamphetamine abstinence, disruptions to the DMN and executive network may a play key role, providing new insights for early rehabilitation.
format Online
Article
Text
id pubmed-9271316
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-92713162022-07-11 Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence Gong, Mingqiang Shen, Yunxia Liang, Wenbin Zhang, Zhen He, Chunxue Lou, Mingwu Xu, ZiYu Int J Gen Med Original Research PURPOSE: Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments detected by neuroimaging in methamphetamine abstainers (MAs) during short-term abstinence. This study aimed to investigate effective connectivity, resting-state networks, and internetwork functional connectivity in MA brains to improve clinical treatment. METHODS: Twenty MAs and 27 age- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging. The amplitude of low-frequency fluctuations and Granger causality were analyzed to investigate disrupted brain regions and effective connectivity, respectively. Independent component analysis and functional network connectivity were used to identify resting-state networks and internetwork functional connectivity, respectively. RESULTS: Compared with healthy controls, MAs demonstrated abnormal amplitudes of low-frequency fluctuations in the bilateral precuneus, left posterior cingulate cortex (PCC), left middle frontal gyrus (MFG), left superior parietal lobule, left supplementary motor area (SMA), and left inferior parietal lobule (IPL). Moreover, MAs showed decreased effective connectivity from the left PCC to the left precuneus, increased effective connectivity from the left precuneus to the left MFG and from the right precuneus to the left SMA, and altered functional connectivity within the default mode network (DMN), frontoparietal network, sensorimotor network, ventral attention network, cerebellar network, and visual network. Importantly, hyperconnectivity between the DMN and ventral attention network and hypoconnectivity between the DMN and cerebellar network as well as the DMN and frontoparietal network were demonstrated in MAs. CONCLUSION: Our study implies that in short-term methamphetamine abstinence, disruptions to the DMN and executive network may a play key role, providing new insights for early rehabilitation. Dove 2022-07-06 /pmc/articles/PMC9271316/ /pubmed/35821766 http://dx.doi.org/10.2147/IJGM.S369571 Text en © 2022 Gong et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Gong, Mingqiang
Shen, Yunxia
Liang, Wenbin
Zhang, Zhen
He, Chunxue
Lou, Mingwu
Xu, ZiYu
Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title_full Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title_fullStr Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title_full_unstemmed Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title_short Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence
title_sort impairments in the default mode and executive networks in methamphetamine users during short-term abstinence
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271316/
https://www.ncbi.nlm.nih.gov/pubmed/35821766
http://dx.doi.org/10.2147/IJGM.S369571
work_keys_str_mv AT gongmingqiang impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT shenyunxia impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT liangwenbin impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT zhangzhen impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT hechunxue impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT loumingwu impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence
AT xuziyu impairmentsinthedefaultmodeandexecutivenetworksinmethamphetamineusersduringshorttermabstinence