Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2

Immunoglobulin E (IgE) responses are a central feature of allergic disease. Using a well-established food-allergy model in mice, we show that two sensitizations with cognate B cell antigen (Ag) and adjuvant 7 days apart promotes optimal development of IgE+ germinal center (GC) B cells and high-affin...

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Detalles Bibliográficos
Autores principales: Chen, Qiang, Xie, Markus, Liu, Hong, Dent, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271337/
https://www.ncbi.nlm.nih.gov/pubmed/35767958
http://dx.doi.org/10.1016/j.celrep.2022.110990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271337/
https://www.ncbi.nlm.nih.gov/pubmed/35767958
http://dx.doi.org/10.1016/j.celrep.2022.110990

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