Cargando…

Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study

OBJECTIVES: Multisystem inflammatory syndrome in children (MIS-C) is the result of an immune response triggered by a previous exposure to SARS-CoV-2. The clinical presentation of MIS-C overlaps with other life-threatening bacterial infections, in which antimicrobials are the mainstay therapy. The ai...

Descripción completa

Detalles Bibliográficos
Autores principales: Toczyłowski, Kacper, Łasecka-Zadrożna, Joanna, Pałyga-Bysiecka, Ilona, Ludwikowska, Kamila Maria, Okarska-Napierała, Magdalena, Dudek, Natalia, Afelt, Aneta, Suski, Catherine, Kursa, Miron Bartosz, Jackowska, Teresa, Kuchar, Ernest, Szenborn, Leszek, Mazur-Melewska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271354/
https://www.ncbi.nlm.nih.gov/pubmed/35830922
http://dx.doi.org/10.1016/j.ijid.2022.07.021
_version_ 1784744661610397696
author Toczyłowski, Kacper
Łasecka-Zadrożna, Joanna
Pałyga-Bysiecka, Ilona
Ludwikowska, Kamila Maria
Okarska-Napierała, Magdalena
Dudek, Natalia
Afelt, Aneta
Suski, Catherine
Kursa, Miron Bartosz
Jackowska, Teresa
Kuchar, Ernest
Szenborn, Leszek
Mazur-Melewska, Katarzyna
author_facet Toczyłowski, Kacper
Łasecka-Zadrożna, Joanna
Pałyga-Bysiecka, Ilona
Ludwikowska, Kamila Maria
Okarska-Napierała, Magdalena
Dudek, Natalia
Afelt, Aneta
Suski, Catherine
Kursa, Miron Bartosz
Jackowska, Teresa
Kuchar, Ernest
Szenborn, Leszek
Mazur-Melewska, Katarzyna
author_sort Toczyłowski, Kacper
collection PubMed
description OBJECTIVES: Multisystem inflammatory syndrome in children (MIS-C) is the result of an immune response triggered by a previous exposure to SARS-CoV-2. The clinical presentation of MIS-C overlaps with other life-threatening bacterial infections, in which antimicrobials are the mainstay therapy. The aim of study was to describe the use of antibiotics in children with MIS-C in Poland. METHODS: The analysis of 345 children reported from 42 Polish cities to the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR Study) from June 2020 to April 2021. RESULTS: At least one antibiotic was used in 310 (90%) children, mainly third-generation cephalosporin (251/310). Broad-spectrum antibiotics were used in 258 (75%) children and 224 (87%) received this treatment for more than 3 days. Concentrations of serum procalcitonin >2 µg/l and the presence of lower respiratory symptoms were associated with increased odds of receiving any antibiotic. CONCLUSION: Although bacterial infections in patients with MIS-C are uncommon, we show that MIS-C poses a challenge to clinicians who are faced with the decision to start, continue, or stop antimicrobial therapy. Antibiotic stewardship in patients with MIS-C should be improved to ensure that likely pathogens are treated and that antimicrobials are stopped when bacterial infections are excluded and the diagnosis of MIS-C is made.
format Online
Article
Text
id pubmed-9271354
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
record_format MEDLINE/PubMed
spelling pubmed-92713542022-07-11 Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study Toczyłowski, Kacper Łasecka-Zadrożna, Joanna Pałyga-Bysiecka, Ilona Ludwikowska, Kamila Maria Okarska-Napierała, Magdalena Dudek, Natalia Afelt, Aneta Suski, Catherine Kursa, Miron Bartosz Jackowska, Teresa Kuchar, Ernest Szenborn, Leszek Mazur-Melewska, Katarzyna Int J Infect Dis Article OBJECTIVES: Multisystem inflammatory syndrome in children (MIS-C) is the result of an immune response triggered by a previous exposure to SARS-CoV-2. The clinical presentation of MIS-C overlaps with other life-threatening bacterial infections, in which antimicrobials are the mainstay therapy. The aim of study was to describe the use of antibiotics in children with MIS-C in Poland. METHODS: The analysis of 345 children reported from 42 Polish cities to the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR Study) from June 2020 to April 2021. RESULTS: At least one antibiotic was used in 310 (90%) children, mainly third-generation cephalosporin (251/310). Broad-spectrum antibiotics were used in 258 (75%) children and 224 (87%) received this treatment for more than 3 days. Concentrations of serum procalcitonin >2 µg/l and the presence of lower respiratory symptoms were associated with increased odds of receiving any antibiotic. CONCLUSION: Although bacterial infections in patients with MIS-C are uncommon, we show that MIS-C poses a challenge to clinicians who are faced with the decision to start, continue, or stop antimicrobial therapy. Antibiotic stewardship in patients with MIS-C should be improved to ensure that likely pathogens are treated and that antimicrobials are stopped when bacterial infections are excluded and the diagnosis of MIS-C is made. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-09 2022-07-10 /pmc/articles/PMC9271354/ /pubmed/35830922 http://dx.doi.org/10.1016/j.ijid.2022.07.021 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Toczyłowski, Kacper
Łasecka-Zadrożna, Joanna
Pałyga-Bysiecka, Ilona
Ludwikowska, Kamila Maria
Okarska-Napierała, Magdalena
Dudek, Natalia
Afelt, Aneta
Suski, Catherine
Kursa, Miron Bartosz
Jackowska, Teresa
Kuchar, Ernest
Szenborn, Leszek
Mazur-Melewska, Katarzyna
Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title_full Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title_fullStr Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title_full_unstemmed Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title_short Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
title_sort use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with sars-cov-2 infection in poland: the mois-cor study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271354/
https://www.ncbi.nlm.nih.gov/pubmed/35830922
http://dx.doi.org/10.1016/j.ijid.2022.07.021
work_keys_str_mv AT toczyłowskikacper useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT łaseckazadroznajoanna useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT pałygabysieckailona useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT ludwikowskakamilamaria useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT okarskanapierałamagdalena useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT dudeknatalia useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT afeltaneta useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT suskicatherine useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT kursamironbartosz useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT jackowskateresa useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT kucharernest useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT szenbornleszek useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy
AT mazurmelewskakatarzyna useofbroadspectrumantibioticsinchildrendiagnosedwithmultisysteminflammatorysyndrometemporarilyassociatedwithsarscov2infectioninpolandthemoiscorstudy