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Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting

BACKGROUND: There is a gap in antimicrobial stewardship in transitions of care. OBJECTIVES: To assess the appropriateness of antibiotics utilized and prescribing habits at hospital discharge. METHODS: A retrospective, observational study was conducted at our quaternary care hospital between January...

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Autores principales: Saleh, Joanna, El Nekidy, Wasim S, El Lababidi, Rania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271486/
https://www.ncbi.nlm.nih.gov/pubmed/35821743
http://dx.doi.org/10.1093/jacamr/dlac065
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author Saleh, Joanna
El Nekidy, Wasim S
El Lababidi, Rania
author_facet Saleh, Joanna
El Nekidy, Wasim S
El Lababidi, Rania
author_sort Saleh, Joanna
collection PubMed
description BACKGROUND: There is a gap in antimicrobial stewardship in transitions of care. OBJECTIVES: To assess the appropriateness of antibiotics utilized and prescribing habits at hospital discharge. METHODS: A retrospective, observational study was conducted at our quaternary care hospital between January 2021 and March 2021. During the study period, all patients discharged on antibiotics for pneumonia (PNA), skin and soft tissue infections (SSTI), urinary tract infections (UTI) and intra-abdominal infections (IAI) were included. The overall appropriateness of therapy was assessed based on the following combined criteria: agent, dose, frequency, duration of therapy, and ability to meet diagnostic criteria. RESULTS: One hundred and forty-five subjects met the inclusion criteria. Of these, 44 (30.3%) were determined to have received overall appropriate antibiotic therapy. The most common infections were UTI, followed by IAI, PNA, and SSTI, respectively. Further, from the group deemed to have received overall inappropriate therapy, 26 of the 101 (25.7%) patients received an inappropriate antibiotic choice, 6 (5.9%) an inappropriate dose, and 84 (83.2%) an inappropriate duration of therapy. CONCLUSIONS: Inappropriate duration of therapy represented the most challenging problem with antibiotic regimens at discharge. Larger studies are needed to identify potential interventions that are effective, and can be implemented in all settings, including resource-limited ones.
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spelling pubmed-92714862022-07-11 Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting Saleh, Joanna El Nekidy, Wasim S El Lababidi, Rania JAC Antimicrob Resist Brief Report BACKGROUND: There is a gap in antimicrobial stewardship in transitions of care. OBJECTIVES: To assess the appropriateness of antibiotics utilized and prescribing habits at hospital discharge. METHODS: A retrospective, observational study was conducted at our quaternary care hospital between January 2021 and March 2021. During the study period, all patients discharged on antibiotics for pneumonia (PNA), skin and soft tissue infections (SSTI), urinary tract infections (UTI) and intra-abdominal infections (IAI) were included. The overall appropriateness of therapy was assessed based on the following combined criteria: agent, dose, frequency, duration of therapy, and ability to meet diagnostic criteria. RESULTS: One hundred and forty-five subjects met the inclusion criteria. Of these, 44 (30.3%) were determined to have received overall appropriate antibiotic therapy. The most common infections were UTI, followed by IAI, PNA, and SSTI, respectively. Further, from the group deemed to have received overall inappropriate therapy, 26 of the 101 (25.7%) patients received an inappropriate antibiotic choice, 6 (5.9%) an inappropriate dose, and 84 (83.2%) an inappropriate duration of therapy. CONCLUSIONS: Inappropriate duration of therapy represented the most challenging problem with antibiotic regimens at discharge. Larger studies are needed to identify potential interventions that are effective, and can be implemented in all settings, including resource-limited ones. Oxford University Press 2022-07-11 /pmc/articles/PMC9271486/ /pubmed/35821743 http://dx.doi.org/10.1093/jacamr/dlac065 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Saleh, Joanna
El Nekidy, Wasim S
El Lababidi, Rania
Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title_full Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title_fullStr Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title_full_unstemmed Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title_short Assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
title_sort assessment of antibiotic appropriateness at discharge: experience from a quaternary care hospital setting
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271486/
https://www.ncbi.nlm.nih.gov/pubmed/35821743
http://dx.doi.org/10.1093/jacamr/dlac065
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