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Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signalin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271624/ https://www.ncbi.nlm.nih.gov/pubmed/35832432 http://dx.doi.org/10.3389/fendo.2022.922825 |
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author | Pablos, Marta Casanueva-Álvarez, Elena González-Casimiro, Carlos M. Merino, Beatriz Perdomo, Germán Cózar-Castellano, Irene |
author_facet | Pablos, Marta Casanueva-Álvarez, Elena González-Casimiro, Carlos M. Merino, Beatriz Perdomo, Germán Cózar-Castellano, Irene |
author_sort | Pablos, Marta |
collection | PubMed |
description | The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis. |
format | Online Article Text |
id | pubmed-9271624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92716242022-07-12 Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme Pablos, Marta Casanueva-Álvarez, Elena González-Casimiro, Carlos M. Merino, Beatriz Perdomo, Germán Cózar-Castellano, Irene Front Endocrinol (Lausanne) Endocrinology The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9271624/ /pubmed/35832432 http://dx.doi.org/10.3389/fendo.2022.922825 Text en Copyright © 2022 Pablos, Casanueva-Álvarez, González-Casimiro, Merino, Perdomo and Cózar-Castellano https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Pablos, Marta Casanueva-Álvarez, Elena González-Casimiro, Carlos M. Merino, Beatriz Perdomo, Germán Cózar-Castellano, Irene Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title | Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title_full | Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title_fullStr | Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title_full_unstemmed | Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title_short | Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
title_sort | primary cilia in pancreatic β- and α-cells: time to revisit the role of insulin-degrading enzyme |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271624/ https://www.ncbi.nlm.nih.gov/pubmed/35832432 http://dx.doi.org/10.3389/fendo.2022.922825 |
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