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Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signalin...

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Autores principales: Pablos, Marta, Casanueva-Álvarez, Elena, González-Casimiro, Carlos M., Merino, Beatriz, Perdomo, Germán, Cózar-Castellano, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271624/
https://www.ncbi.nlm.nih.gov/pubmed/35832432
http://dx.doi.org/10.3389/fendo.2022.922825
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author Pablos, Marta
Casanueva-Álvarez, Elena
González-Casimiro, Carlos M.
Merino, Beatriz
Perdomo, Germán
Cózar-Castellano, Irene
author_facet Pablos, Marta
Casanueva-Álvarez, Elena
González-Casimiro, Carlos M.
Merino, Beatriz
Perdomo, Germán
Cózar-Castellano, Irene
author_sort Pablos, Marta
collection PubMed
description The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis.
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spelling pubmed-92716242022-07-12 Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme Pablos, Marta Casanueva-Álvarez, Elena González-Casimiro, Carlos M. Merino, Beatriz Perdomo, Germán Cózar-Castellano, Irene Front Endocrinol (Lausanne) Endocrinology The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9271624/ /pubmed/35832432 http://dx.doi.org/10.3389/fendo.2022.922825 Text en Copyright © 2022 Pablos, Casanueva-Álvarez, González-Casimiro, Merino, Perdomo and Cózar-Castellano https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Pablos, Marta
Casanueva-Álvarez, Elena
González-Casimiro, Carlos M.
Merino, Beatriz
Perdomo, Germán
Cózar-Castellano, Irene
Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title_full Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title_fullStr Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title_full_unstemmed Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title_short Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
title_sort primary cilia in pancreatic β- and α-cells: time to revisit the role of insulin-degrading enzyme
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271624/
https://www.ncbi.nlm.nih.gov/pubmed/35832432
http://dx.doi.org/10.3389/fendo.2022.922825
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