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Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants

PURPOSE: Both air pollutant exposure and neonatal jaundice (NJ) have known effects on childhood asthma, but a higher total serum bilirubin (TSB) level has been associated with lung protection. This study aimed to assess whether prenatal/postnatal exposure to ambient air pollutants is related to the...

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Autores principales: Chung, Hao-Wei, Hsieh, Hui-Min, Lee, Chung-Hsiang, Lin, Yi-Ching, Tsao, Yu-Hsiang, Wu, Huang-Wei, Kuo, Fu-Chen, Hung, Chih-Hsing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271683/
https://www.ncbi.nlm.nih.gov/pubmed/35832831
http://dx.doi.org/10.2147/JIR.S366336
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author Chung, Hao-Wei
Hsieh, Hui-Min
Lee, Chung-Hsiang
Lin, Yi-Ching
Tsao, Yu-Hsiang
Wu, Huang-Wei
Kuo, Fu-Chen
Hung, Chih-Hsing
author_facet Chung, Hao-Wei
Hsieh, Hui-Min
Lee, Chung-Hsiang
Lin, Yi-Ching
Tsao, Yu-Hsiang
Wu, Huang-Wei
Kuo, Fu-Chen
Hung, Chih-Hsing
author_sort Chung, Hao-Wei
collection PubMed
description PURPOSE: Both air pollutant exposure and neonatal jaundice (NJ) have known effects on childhood asthma, but a higher total serum bilirubin (TSB) level has been associated with lung protection. This study aimed to assess whether prenatal/postnatal exposure to ambient air pollutants is related to the development of asthma in infants with NJ. PATIENTS AND METHODS: A nested case–control retrospective study was performed using the data of infants with NJ in the Kaohsiung Medical University Hospital Research Database. Data on average ambient air pollution concentrations within six months, the first year and second year after birth, and in the first, second and third prenatal trimesters were collected. NJ was defined as TSB levels ≥ 2 mg/dl with the diagnosis less than one-month-old. Asthma was defined as a diagnosis with medication use. We constructed conditional logistic regression models to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). RESULTS: Exposure to NO and SO(2) at all six time points in the study was significantly associated with an increased risk of preschool asthma in infants with NJ. The overall peak OR (95% CI) of SO(2), PM(2.5), PM(10), NO, NO(2), and NO(X) were 1.277 (1.129–1.444), 1.057 (1.023–1.092), 1.035 (1.011–1.059), 1.272 (1.111–1.455), 1.168 (1.083–1.259) and 1.104 (1.051–1.161), respectively. Fetuses in the first and second trimester were most vulnerable to ambient air pollutant exposure such as SO(2) PM(2.5), NO, NO(2) and NO(X) during the prenatal period. Exposure to all six ambient air pollutants during the first and second years after birth significantly affected preschool asthma in NJ infants. CONCLUSION: In different time windows, prenatal and postnatal exposure to SO(2), PM(2.5), PM(10), NO, NO(2), and NO(X) were associated with preschool asthma in NJ infants. The relatively high impact of NO and SO(2) exposure in infants with NJ requires further studies and prevention measures.
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spelling pubmed-92716832022-07-12 Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants Chung, Hao-Wei Hsieh, Hui-Min Lee, Chung-Hsiang Lin, Yi-Ching Tsao, Yu-Hsiang Wu, Huang-Wei Kuo, Fu-Chen Hung, Chih-Hsing J Inflamm Res Original Research PURPOSE: Both air pollutant exposure and neonatal jaundice (NJ) have known effects on childhood asthma, but a higher total serum bilirubin (TSB) level has been associated with lung protection. This study aimed to assess whether prenatal/postnatal exposure to ambient air pollutants is related to the development of asthma in infants with NJ. PATIENTS AND METHODS: A nested case–control retrospective study was performed using the data of infants with NJ in the Kaohsiung Medical University Hospital Research Database. Data on average ambient air pollution concentrations within six months, the first year and second year after birth, and in the first, second and third prenatal trimesters were collected. NJ was defined as TSB levels ≥ 2 mg/dl with the diagnosis less than one-month-old. Asthma was defined as a diagnosis with medication use. We constructed conditional logistic regression models to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). RESULTS: Exposure to NO and SO(2) at all six time points in the study was significantly associated with an increased risk of preschool asthma in infants with NJ. The overall peak OR (95% CI) of SO(2), PM(2.5), PM(10), NO, NO(2), and NO(X) were 1.277 (1.129–1.444), 1.057 (1.023–1.092), 1.035 (1.011–1.059), 1.272 (1.111–1.455), 1.168 (1.083–1.259) and 1.104 (1.051–1.161), respectively. Fetuses in the first and second trimester were most vulnerable to ambient air pollutant exposure such as SO(2) PM(2.5), NO, NO(2) and NO(X) during the prenatal period. Exposure to all six ambient air pollutants during the first and second years after birth significantly affected preschool asthma in NJ infants. CONCLUSION: In different time windows, prenatal and postnatal exposure to SO(2), PM(2.5), PM(10), NO, NO(2), and NO(X) were associated with preschool asthma in NJ infants. The relatively high impact of NO and SO(2) exposure in infants with NJ requires further studies and prevention measures. Dove 2022-07-06 /pmc/articles/PMC9271683/ /pubmed/35832831 http://dx.doi.org/10.2147/JIR.S366336 Text en © 2022 Chung et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Chung, Hao-Wei
Hsieh, Hui-Min
Lee, Chung-Hsiang
Lin, Yi-Ching
Tsao, Yu-Hsiang
Wu, Huang-Wei
Kuo, Fu-Chen
Hung, Chih-Hsing
Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title_full Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title_fullStr Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title_full_unstemmed Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title_short Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
title_sort prenatal and postnatal exposure to ambient air pollution and preschool asthma in neonatal jaundice infants
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271683/
https://www.ncbi.nlm.nih.gov/pubmed/35832831
http://dx.doi.org/10.2147/JIR.S366336
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