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Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis

OBJECTIVE: To evaluate the efficacy and safety of oropharyngeal administration of colostrum (OAC) in preterm infants. METHODS: We searched Embase, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the website of...

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Autores principales: Huo, Mengyue, Liu, Chunli, Mei, Hua, Zhang, Yuheng, Liu, Chunzhi, Song, Dan, Zhang, Yayu, Zhang, Yanbo, Xin, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271762/
https://www.ncbi.nlm.nih.gov/pubmed/35832583
http://dx.doi.org/10.3389/fped.2022.895375
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author Huo, Mengyue
Liu, Chunli
Mei, Hua
Zhang, Yuheng
Liu, Chunzhi
Song, Dan
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
author_facet Huo, Mengyue
Liu, Chunli
Mei, Hua
Zhang, Yuheng
Liu, Chunzhi
Song, Dan
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
author_sort Huo, Mengyue
collection PubMed
description OBJECTIVE: To evaluate the efficacy and safety of oropharyngeal administration of colostrum (OAC) in preterm infants. METHODS: We searched Embase, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the website of the clinical trials, search time was from the establishment of the databases or websites up to 1 February 2022. Preterm infants with gestational age (GA) ≤ 32 weeks or birth weight (BW) ≤ 1500 g were taken as the participants, collect randomized controlled trials (RCTs) of comparing OAC and placebo or no intervention in preterm infants. Two researchers independently screened the literature, extracted the data, and evaluated the quality of the literature, and we adopted Review Manager 5.3 software for meta-analysis. RESULTS: In total, 11 RCTs (n = 1,173) were included in the review. A meta-analysis showed significant difference in the incidence of necrotizing enterocolitis [NEC; p = 0.009, relative ratio (RR) = 0.51, 95% confidence interval (CI) = 0.31–0.84], late-onset sepsis (LOS; p = 0.02, RR = 0.75, 95% CI = 0.59–0.95), ventilator-associated pneumonia (VAP; p = 0.03, RR = 0.48, 95% CI = 0.24–0.95), the time to reach full enteral feeds (p < 0.00001, mean difference (MD) = −3.40, 95% CI = −3.87 to −2.92), duration of hospital stay (p < 0.00001, MD = −10.00, 95% CI = −11.36 to −8.64), and the rate of weight gain (kg.d; p < 0.00001, MD = 2.63, 95% CI = 2.10–3.16) between the colostrum group and control group. Meanwhile, researchers found no significant difference between the colostrum group and control group in the incidence of bronchopulmonary dysplasia (BPD; p = 0.17, RR = 0.83, 95% CI = 0.64–1.08), intraventricular hemorrhage (IVH; grade ≥3; p = 0.05, RR = 0.44, 95% CI = 0.19–1.01), periventricular leukomalacia (PVL; p = 0.67, RR = 0.70, 95% CI = 0.14–3.49), retinopathy of prematurity (ROP; p = 0.29, RR = 1.25, 95% CI = 0.82–1.89), and patent ductus arteriosus (PDA; p = 0.17, RR = 1.22, 95% CI = 0.92–1.62). CONCLUSION: Oropharyngeal administration of colostrum can reduce the incidence of NEC, LOS, and VAP in preterm infants, shortening the time to reach full enteral feeds, and duration of hospital stay, and increasing the rate of weight gain (kg.d). Therefore, OAC can be used as part of routine care for preterm infants.
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spelling pubmed-92717622022-07-12 Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis Huo, Mengyue Liu, Chunli Mei, Hua Zhang, Yuheng Liu, Chunzhi Song, Dan Zhang, Yayu Zhang, Yanbo Xin, Chun Front Pediatr Pediatrics OBJECTIVE: To evaluate the efficacy and safety of oropharyngeal administration of colostrum (OAC) in preterm infants. METHODS: We searched Embase, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the website of the clinical trials, search time was from the establishment of the databases or websites up to 1 February 2022. Preterm infants with gestational age (GA) ≤ 32 weeks or birth weight (BW) ≤ 1500 g were taken as the participants, collect randomized controlled trials (RCTs) of comparing OAC and placebo or no intervention in preterm infants. Two researchers independently screened the literature, extracted the data, and evaluated the quality of the literature, and we adopted Review Manager 5.3 software for meta-analysis. RESULTS: In total, 11 RCTs (n = 1,173) were included in the review. A meta-analysis showed significant difference in the incidence of necrotizing enterocolitis [NEC; p = 0.009, relative ratio (RR) = 0.51, 95% confidence interval (CI) = 0.31–0.84], late-onset sepsis (LOS; p = 0.02, RR = 0.75, 95% CI = 0.59–0.95), ventilator-associated pneumonia (VAP; p = 0.03, RR = 0.48, 95% CI = 0.24–0.95), the time to reach full enteral feeds (p < 0.00001, mean difference (MD) = −3.40, 95% CI = −3.87 to −2.92), duration of hospital stay (p < 0.00001, MD = −10.00, 95% CI = −11.36 to −8.64), and the rate of weight gain (kg.d; p < 0.00001, MD = 2.63, 95% CI = 2.10–3.16) between the colostrum group and control group. Meanwhile, researchers found no significant difference between the colostrum group and control group in the incidence of bronchopulmonary dysplasia (BPD; p = 0.17, RR = 0.83, 95% CI = 0.64–1.08), intraventricular hemorrhage (IVH; grade ≥3; p = 0.05, RR = 0.44, 95% CI = 0.19–1.01), periventricular leukomalacia (PVL; p = 0.67, RR = 0.70, 95% CI = 0.14–3.49), retinopathy of prematurity (ROP; p = 0.29, RR = 1.25, 95% CI = 0.82–1.89), and patent ductus arteriosus (PDA; p = 0.17, RR = 1.22, 95% CI = 0.92–1.62). CONCLUSION: Oropharyngeal administration of colostrum can reduce the incidence of NEC, LOS, and VAP in preterm infants, shortening the time to reach full enteral feeds, and duration of hospital stay, and increasing the rate of weight gain (kg.d). Therefore, OAC can be used as part of routine care for preterm infants. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9271762/ /pubmed/35832583 http://dx.doi.org/10.3389/fped.2022.895375 Text en Copyright © 2022 Huo, Liu, Mei, Zhang, Liu, Song, Zhang, Zhang and Xin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Huo, Mengyue
Liu, Chunli
Mei, Hua
Zhang, Yuheng
Liu, Chunzhi
Song, Dan
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title_full Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title_fullStr Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title_full_unstemmed Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title_short Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis
title_sort intervention effect of oropharyngeal administration of colostrum in preterm infants: a meta-analysis
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271762/
https://www.ncbi.nlm.nih.gov/pubmed/35832583
http://dx.doi.org/10.3389/fped.2022.895375
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