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Heterogeneity and Function of Kupffer Cells in Liver Injury
Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of hepatic macrophages even body tissue macrophages. They reside in liver sinusoids towards portal vein. The micro-environment shapes KCs unique immunosuppressive features and functions. KCs express specific surfac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271789/ https://www.ncbi.nlm.nih.gov/pubmed/35833135 http://dx.doi.org/10.3389/fimmu.2022.940867 |
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author | Li, Weiyang Chang, Na Li, Liying |
author_facet | Li, Weiyang Chang, Na Li, Liying |
author_sort | Li, Weiyang |
collection | PubMed |
description | Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of hepatic macrophages even body tissue macrophages. They reside in liver sinusoids towards portal vein. The micro-environment shapes KCs unique immunosuppressive features and functions. KCs express specific surface markers that distinguish from other liver macrophages. By engulfing gut-derived foreign products and apoptotic cells without triggering excessive inflammation, KCs maintain homeostasis of liver and body. Heterogeneity of KCs has been identified in different studies. In terms of the origin, adult KCs are derived from progenitors of both embryo and adult bone marrow. Embryo-derived KCs compose the majority of KCs in healthy and maintain by self-renewal. Bone marrow monocytes replenish massively when embryo-derived KC proliferation are impaired. The phenotype of KCs is also beyond the traditional dogma of M1-M2. Functionally, KCs play central roles in pathogenesis of acute and chronic liver injury. They contribute to each pathological stage of liver disease. By initiating inflammation, regulating fibrosis, cirrhosis and tumor cell proliferation, KCs contribute to the resolution of liver injury and restoration of tissue architecture. The underlying mechanism varied by damage factors and pathology. Understanding the characteristics and functions of KCs may provide opportunities for the therapy of liver injury. Herein, we attempt to afford insights on heterogeneity and functions of KCs in liver injury using the existing findings. |
format | Online Article Text |
id | pubmed-9271789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92717892022-07-12 Heterogeneity and Function of Kupffer Cells in Liver Injury Li, Weiyang Chang, Na Li, Liying Front Immunol Immunology Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of hepatic macrophages even body tissue macrophages. They reside in liver sinusoids towards portal vein. The micro-environment shapes KCs unique immunosuppressive features and functions. KCs express specific surface markers that distinguish from other liver macrophages. By engulfing gut-derived foreign products and apoptotic cells without triggering excessive inflammation, KCs maintain homeostasis of liver and body. Heterogeneity of KCs has been identified in different studies. In terms of the origin, adult KCs are derived from progenitors of both embryo and adult bone marrow. Embryo-derived KCs compose the majority of KCs in healthy and maintain by self-renewal. Bone marrow monocytes replenish massively when embryo-derived KC proliferation are impaired. The phenotype of KCs is also beyond the traditional dogma of M1-M2. Functionally, KCs play central roles in pathogenesis of acute and chronic liver injury. They contribute to each pathological stage of liver disease. By initiating inflammation, regulating fibrosis, cirrhosis and tumor cell proliferation, KCs contribute to the resolution of liver injury and restoration of tissue architecture. The underlying mechanism varied by damage factors and pathology. Understanding the characteristics and functions of KCs may provide opportunities for the therapy of liver injury. Herein, we attempt to afford insights on heterogeneity and functions of KCs in liver injury using the existing findings. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9271789/ /pubmed/35833135 http://dx.doi.org/10.3389/fimmu.2022.940867 Text en Copyright © 2022 Li, Chang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Weiyang Chang, Na Li, Liying Heterogeneity and Function of Kupffer Cells in Liver Injury |
title | Heterogeneity and Function of Kupffer Cells in Liver Injury |
title_full | Heterogeneity and Function of Kupffer Cells in Liver Injury |
title_fullStr | Heterogeneity and Function of Kupffer Cells in Liver Injury |
title_full_unstemmed | Heterogeneity and Function of Kupffer Cells in Liver Injury |
title_short | Heterogeneity and Function of Kupffer Cells in Liver Injury |
title_sort | heterogeneity and function of kupffer cells in liver injury |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271789/ https://www.ncbi.nlm.nih.gov/pubmed/35833135 http://dx.doi.org/10.3389/fimmu.2022.940867 |
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