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Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients

The liver is a primary organ that stores body iron, and plays a central role in the regulation of iron homeostasis. Hepatic iron overload (HIO) is a prevalent feature among patients with chronic liver diseases (CLDs), including alcoholic/nonalcoholic liver diseases and hepatitis C. HIO is suggested...

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Autor principal: Tsuchiya, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271801/
https://www.ncbi.nlm.nih.gov/pubmed/35832553
http://dx.doi.org/10.3389/fonc.2022.940552
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author Tsuchiya, Hiroyuki
author_facet Tsuchiya, Hiroyuki
author_sort Tsuchiya, Hiroyuki
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description The liver is a primary organ that stores body iron, and plays a central role in the regulation of iron homeostasis. Hepatic iron overload (HIO) is a prevalent feature among patients with chronic liver diseases (CLDs), including alcoholic/nonalcoholic liver diseases and hepatitis C. HIO is suggested to promote the progression toward hepatocellular carcinoma because of the pro-oxidant nature of iron. Iron metabolism is tightly regulated by various factors, such as hepcidin and ferroportin, in healthy individuals to protect the liver from such deteriorative effects. However, their intrinsic expressions or functions are frequently compromised in patients with HIO. Thus, various nutrients have been reported to regulate hepatic iron metabolism and protect the liver from iron-induced damage. These nutrients are beneficial in HIO-associated CLD treatment and eventually prevent iron-mediated hepatocarcinogenesis. This mini-review aimed to discuss the mechanisms and hepatocarcinogenic risk of HIO in patients with CLDs. Moreover, nutrients that hold the potential to prevent iron-induced hepatocarcinogenesis are summarized.
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spelling pubmed-92718012022-07-12 Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients Tsuchiya, Hiroyuki Front Oncol Oncology The liver is a primary organ that stores body iron, and plays a central role in the regulation of iron homeostasis. Hepatic iron overload (HIO) is a prevalent feature among patients with chronic liver diseases (CLDs), including alcoholic/nonalcoholic liver diseases and hepatitis C. HIO is suggested to promote the progression toward hepatocellular carcinoma because of the pro-oxidant nature of iron. Iron metabolism is tightly regulated by various factors, such as hepcidin and ferroportin, in healthy individuals to protect the liver from such deteriorative effects. However, their intrinsic expressions or functions are frequently compromised in patients with HIO. Thus, various nutrients have been reported to regulate hepatic iron metabolism and protect the liver from iron-induced damage. These nutrients are beneficial in HIO-associated CLD treatment and eventually prevent iron-mediated hepatocarcinogenesis. This mini-review aimed to discuss the mechanisms and hepatocarcinogenic risk of HIO in patients with CLDs. Moreover, nutrients that hold the potential to prevent iron-induced hepatocarcinogenesis are summarized. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9271801/ /pubmed/35832553 http://dx.doi.org/10.3389/fonc.2022.940552 Text en Copyright © 2022 Tsuchiya https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tsuchiya, Hiroyuki
Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title_full Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title_fullStr Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title_full_unstemmed Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title_short Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
title_sort iron-induced hepatocarcinogenesis—preventive effects of nutrients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271801/
https://www.ncbi.nlm.nih.gov/pubmed/35832553
http://dx.doi.org/10.3389/fonc.2022.940552
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