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Evaluation of P57, P53 and Ki67 Expression in Meningiomas
OBJECTIVE: We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of proliferative markers and tumor suppressor proteins. METHODS: The study included 29 patients with pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurosurgical Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271805/ https://www.ncbi.nlm.nih.gov/pubmed/35418006 http://dx.doi.org/10.3340/jkns.2021.0197 |
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author | Küçükosmanoğlu, İlknur Karanis, Meryem İlkay Eren Ünlü, Yaşar Çöven, İlker |
author_facet | Küçükosmanoğlu, İlknur Karanis, Meryem İlkay Eren Ünlü, Yaşar Çöven, İlker |
author_sort | Küçükosmanoğlu, İlknur |
collection | PubMed |
description | OBJECTIVE: We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of proliferative markers and tumor suppressor proteins. METHODS: The study included 29 patients with primary intracranial and intraspinal meningioma diagnosed in the pathology laboratory of Konya City Hospital between January 2014 and December 2020. Clinicopathological characteristics of the patients including parameters such as age and gender were obtained from the hospital records. Histopathological findings were obtained by re-evaluating the preparations stained with Hematoxylin-Eosin, which were extracted from the archive, and by evaluating new sections obtained from paraffin blocks of patients stained with Ki67, p53, and p57 immunohistochemical stains. RESULTS: A moderate correlation was found between tumor size and Ki67 proliferation index (PI) (p=0.003, r=0.530). There was no significant difference between grade I and grade II tumors in terms of p53 (p=0.184) and p57 (p=0.487) expressions. There were higher levels of Ki67 PI in grade II tumors. The histological subtypes of the tumor had no significant difference with Ki67 PI (p=0.018), p53 (p=0.662), and p57 (p=0.368) expressions. CONCLUSION: In order to obtain more definitive results, there is a need for studies, which are conducted with a greater number of patients and in multiple centers, and in which a long prospective follow-up is planned. The combination of histological, surgical, and imaging markers could make a more sensitive tool for predicting recurrence, and this could also be tested in future studies. |
format | Online Article Text |
id | pubmed-9271805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-92718052022-07-19 Evaluation of P57, P53 and Ki67 Expression in Meningiomas Küçükosmanoğlu, İlknur Karanis, Meryem İlkay Eren Ünlü, Yaşar Çöven, İlker J Korean Neurosurg Soc Laboratory Investigation OBJECTIVE: We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of proliferative markers and tumor suppressor proteins. METHODS: The study included 29 patients with primary intracranial and intraspinal meningioma diagnosed in the pathology laboratory of Konya City Hospital between January 2014 and December 2020. Clinicopathological characteristics of the patients including parameters such as age and gender were obtained from the hospital records. Histopathological findings were obtained by re-evaluating the preparations stained with Hematoxylin-Eosin, which were extracted from the archive, and by evaluating new sections obtained from paraffin blocks of patients stained with Ki67, p53, and p57 immunohistochemical stains. RESULTS: A moderate correlation was found between tumor size and Ki67 proliferation index (PI) (p=0.003, r=0.530). There was no significant difference between grade I and grade II tumors in terms of p53 (p=0.184) and p57 (p=0.487) expressions. There were higher levels of Ki67 PI in grade II tumors. The histological subtypes of the tumor had no significant difference with Ki67 PI (p=0.018), p53 (p=0.662), and p57 (p=0.368) expressions. CONCLUSION: In order to obtain more definitive results, there is a need for studies, which are conducted with a greater number of patients and in multiple centers, and in which a long prospective follow-up is planned. The combination of histological, surgical, and imaging markers could make a more sensitive tool for predicting recurrence, and this could also be tested in future studies. Korean Neurosurgical Society 2022-07 2022-04-14 /pmc/articles/PMC9271805/ /pubmed/35418006 http://dx.doi.org/10.3340/jkns.2021.0197 Text en Copyright © 2022 The Korean Neurosurgical Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Laboratory Investigation Küçükosmanoğlu, İlknur Karanis, Meryem İlkay Eren Ünlü, Yaşar Çöven, İlker Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title | Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title_full | Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title_fullStr | Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title_full_unstemmed | Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title_short | Evaluation of P57, P53 and Ki67 Expression in Meningiomas |
title_sort | evaluation of p57, p53 and ki67 expression in meningiomas |
topic | Laboratory Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271805/ https://www.ncbi.nlm.nih.gov/pubmed/35418006 http://dx.doi.org/10.3340/jkns.2021.0197 |
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