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Structure–Activity Relationship Analysis of Flavonoids and Its Inhibitory Activity Against BACE1 Enzyme Toward a Better Therapy for Alzheimer’s Disease

Drug development in Alzheimer’s disease (AD) suffers from a high attrition rate. In 2021, 117 agents tested in phases I and II and 36 agents tested in phase III were discontinued. Natural product compounds may be good lead compounds for AD as they contain functional groups that are important for bin...

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Detalles Bibliográficos
Autores principales:	Mohamed Yusof, Nur Intan Saidaah, Abdullah, Zafirah Liyana, Othman, Norodiyah, Mohd Fauzi, Fazlin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271896/ https://www.ncbi.nlm.nih.gov/pubmed/35832462 http://dx.doi.org/10.3389/fchem.2022.874615

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