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Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel

Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever...

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Autores principales: Rahim, Fawad, Amin, Said, Noor, Mohammad, Hadi, Khushal Nadir, Aftab, Sana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271932/
https://www.ncbi.nlm.nih.gov/pubmed/35832758
http://dx.doi.org/10.7759/cureus.25840
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author Rahim, Fawad
Amin, Said
Noor, Mohammad
Hadi, Khushal Nadir
Aftab, Sana
author_facet Rahim, Fawad
Amin, Said
Noor, Mohammad
Hadi, Khushal Nadir
Aftab, Sana
author_sort Rahim, Fawad
collection PubMed
description Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever. Abdominal pain may be due to ileal and colonic inflammation/ulceration and mesenteric lymphadenitis. Sometimes, abdominal pain in typhoid is due to ileal perforation leading to peritonitis, and acute appendicitis which needs urgent surgical intervention. Delayed surgical intervention can result in morbidity and sometimes even death. We report a case of XDR S. typhi infection in a 17-year-old female who presented with fever and abdominal pain. During the course of the hospital stay, while she was on appropriate antibiotics, her abdominal pain worsened due to acute appendicitis. She underwent an appendectomy and had an uneventful recovery. This is the first case, to our knowledge, of acute appendicitis caused by XDR S. typhi. Although appropriate antibiotics are the mainstay of treatment for typhoid fever, physicians should be mindful that surgical consultation may be necessary in certain cases.
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spelling pubmed-92719322022-07-12 Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel Rahim, Fawad Amin, Said Noor, Mohammad Hadi, Khushal Nadir Aftab, Sana Cureus Internal Medicine Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever. Abdominal pain may be due to ileal and colonic inflammation/ulceration and mesenteric lymphadenitis. Sometimes, abdominal pain in typhoid is due to ileal perforation leading to peritonitis, and acute appendicitis which needs urgent surgical intervention. Delayed surgical intervention can result in morbidity and sometimes even death. We report a case of XDR S. typhi infection in a 17-year-old female who presented with fever and abdominal pain. During the course of the hospital stay, while she was on appropriate antibiotics, her abdominal pain worsened due to acute appendicitis. She underwent an appendectomy and had an uneventful recovery. This is the first case, to our knowledge, of acute appendicitis caused by XDR S. typhi. Although appropriate antibiotics are the mainstay of treatment for typhoid fever, physicians should be mindful that surgical consultation may be necessary in certain cases. Cureus 2022-06-10 /pmc/articles/PMC9271932/ /pubmed/35832758 http://dx.doi.org/10.7759/cureus.25840 Text en Copyright © 2022, Rahim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Rahim, Fawad
Amin, Said
Noor, Mohammad
Hadi, Khushal Nadir
Aftab, Sana
Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title_full Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title_fullStr Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title_full_unstemmed Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title_short Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
title_sort extensively drug-resistant salmonella typhi infection: from pill to scalpel
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271932/
https://www.ncbi.nlm.nih.gov/pubmed/35832758
http://dx.doi.org/10.7759/cureus.25840
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