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Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel
Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271932/ https://www.ncbi.nlm.nih.gov/pubmed/35832758 http://dx.doi.org/10.7759/cureus.25840 |
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author | Rahim, Fawad Amin, Said Noor, Mohammad Hadi, Khushal Nadir Aftab, Sana |
author_facet | Rahim, Fawad Amin, Said Noor, Mohammad Hadi, Khushal Nadir Aftab, Sana |
author_sort | Rahim, Fawad |
collection | PubMed |
description | Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever. Abdominal pain may be due to ileal and colonic inflammation/ulceration and mesenteric lymphadenitis. Sometimes, abdominal pain in typhoid is due to ileal perforation leading to peritonitis, and acute appendicitis which needs urgent surgical intervention. Delayed surgical intervention can result in morbidity and sometimes even death. We report a case of XDR S. typhi infection in a 17-year-old female who presented with fever and abdominal pain. During the course of the hospital stay, while she was on appropriate antibiotics, her abdominal pain worsened due to acute appendicitis. She underwent an appendectomy and had an uneventful recovery. This is the first case, to our knowledge, of acute appendicitis caused by XDR S. typhi. Although appropriate antibiotics are the mainstay of treatment for typhoid fever, physicians should be mindful that surgical consultation may be necessary in certain cases. |
format | Online Article Text |
id | pubmed-9271932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-92719322022-07-12 Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel Rahim, Fawad Amin, Said Noor, Mohammad Hadi, Khushal Nadir Aftab, Sana Cureus Internal Medicine Water-borne infections like typhoid fever are common in the developing world. The emergence of extensively drug-resistant Salmonella typhi (XDR S. typhi) is of great concern for both local and global public health. Fever, diarrhea, and abdominal pain are the commonest manifestations of typhoid fever. Abdominal pain may be due to ileal and colonic inflammation/ulceration and mesenteric lymphadenitis. Sometimes, abdominal pain in typhoid is due to ileal perforation leading to peritonitis, and acute appendicitis which needs urgent surgical intervention. Delayed surgical intervention can result in morbidity and sometimes even death. We report a case of XDR S. typhi infection in a 17-year-old female who presented with fever and abdominal pain. During the course of the hospital stay, while she was on appropriate antibiotics, her abdominal pain worsened due to acute appendicitis. She underwent an appendectomy and had an uneventful recovery. This is the first case, to our knowledge, of acute appendicitis caused by XDR S. typhi. Although appropriate antibiotics are the mainstay of treatment for typhoid fever, physicians should be mindful that surgical consultation may be necessary in certain cases. Cureus 2022-06-10 /pmc/articles/PMC9271932/ /pubmed/35832758 http://dx.doi.org/10.7759/cureus.25840 Text en Copyright © 2022, Rahim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Rahim, Fawad Amin, Said Noor, Mohammad Hadi, Khushal Nadir Aftab, Sana Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title | Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title_full | Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title_fullStr | Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title_full_unstemmed | Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title_short | Extensively Drug-Resistant Salmonella typhi Infection: From Pill to Scalpel |
title_sort | extensively drug-resistant salmonella typhi infection: from pill to scalpel |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271932/ https://www.ncbi.nlm.nih.gov/pubmed/35832758 http://dx.doi.org/10.7759/cureus.25840 |
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