Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis

Dampening tumor growth by converting tumor-associated macrophages (TAMs) from M2/repair-types to M1/kill-types is of high interest. Here, we show that cryptotanshinone (CPT) can function as an antitumor immune modulator that switches TAMs from an M2 to an M1 phenotype, leading to tumor regression. A...

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Detalles Bibliográficos
Autores principales: Yen, Jia-Hau, Huang, Wei-Chieh, Lin, Shu-Ching, Huang, Yi-Wen, Chio, Wan-Ting, Tsay, Gregory J., Hung, Mien-Chie, Huang, Sheng-Teng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271981/
https://www.ncbi.nlm.nih.gov/pubmed/35860009
http://dx.doi.org/10.1016/j.omto.2022.06.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271981/
https://www.ncbi.nlm.nih.gov/pubmed/35860009
http://dx.doi.org/10.1016/j.omto.2022.06.008

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