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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers have valued the nature of backbone stereochemistry and early on investigated drug properties for the individual stereocenters in dimers or short...

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Detalles Bibliográficos
Autores principales:	Duschmalé, Jörg, Schäublin, Adrian, Funder, Erik, Schmidt, Steffen, Kiełpiński, Łukasz J., Nymark, Helle, Jensen, Klaus, Koch, Troels, Duschmalé, Martina, Koller, Erich, Møller, Marianne Ravn, Schadt, Simone, Husser, Christophe, Brink, Andreas, Sewing, Sabine, Minz, Tanja, Wengel, Jesper, Bleicher, Konrad, Li, Meiling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271985/ https://www.ncbi.nlm.nih.gov/pubmed/35860384 http://dx.doi.org/10.1016/j.omtn.2022.06.010

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