Cargando…

Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium

Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the mechanism of KCa3.1 membrane targeting is poorly und...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farquhar, Rachel E., Cheung, Tanya T., Logue, Matthew J. E., McDonald, Fiona J., Devor, Daniel C., Hamilton, Kirk L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271999/ https://www.ncbi.nlm.nih.gov/pubmed/35832483 http://dx.doi.org/10.3389/fphys.2022.905834

Ejemplares similares

Modulation of Retrograde Trafficking of KCa3.1 in a Polarized Epithelium
por: Lee, Bob Shih-Liang, et al.
Publicado: (2017)

The Role of the Cytoskeleton and Myosin-Vc in the Targeting of KCa3.1 to the Basolateral Membrane of Polarized Epithelial Cells
por: Farquhar, Rachel E., et al.
Publicado: (2017)

Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23
por: Bertuccio, Claudia A., et al.
Publicado: (2018)

Anterograde Trafficking of KCa3.1 in Polarized Epithelia Is Rab1- and Rab8-Dependent and Recycling Endosome-Independent
por: Bertuccio, Claudia A., et al.
Publicado: (2014)

Characterization of the PCMBS-dependent modification of KCa3.1 channel gating
por: Bailey, Mark A., et al.
Publicado: (2010)

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
por: Valero, Marta Sofía, et al.
Publicado: (2019)

LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells
por: Caglioti, Concetta, et al.
Publicado: (2022)

Contribution of the KCa3.1 channel–calmodulin interactions to the regulation of the KCa3.1 gating process
por: Morales, Patricia, et al.
Publicado: (2013)

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C
por: Oliván-Viguera, Aida, et al.
Publicado: (2017)

Investigating CFTR and KCa3.1 Protein/Protein Interactions
por: Klein, Hélène, et al.
Publicado: (2016)

Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease
por: Jin, Lee‐Way, et al.
Publicado: (2019)

Epithelial Na(+) Channel: Reciprocal Control by COMMD10 and Nedd4-2
por: Ware, Adam W., et al.
Publicado: (2018)

KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo
por: D'Alessandro, G, et al.
Publicado: (2013)

KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
por: Brown, Brandon M., et al.
Publicado: (2018)

Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma
por: D’Alessandro, Giuseppina, et al.
Publicado: (2019)

KCa3.1 Impairment Is Not Just a Slow Afterthought in Epilepsy
por: Gross, Christina
Publicado: (2020)

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages
por: Grimaldi, A, et al.
Publicado: (2016)

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3
por: Oliván-Viguera, Aida, et al.
Publicado: (2013)

Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease
por: Maezawa, Izumi, et al.
Publicado: (2012)

Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane
por: Cheung, Tanya T., et al.
Publicado: (2019)

KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis
por: Huang, Chunling, et al.
Publicado: (2014)

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
por: D'Alessandro, Giuseppina, et al.
Publicado: (2016)

KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma
por: Song, Penghong, et al.
Publicado: (2017)

Organization and dynamics of SNARE proteins in the presynaptic membrane
por: Milovanovic, Dragomir, et al.
Publicado: (2015)

The Multifaceted Role of SNARE Proteins in Membrane Fusion
por: Han, Jing, et al.
Publicado: (2017)

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1
por: Srivastava, Shekhar, et al.
Publicado: (2016)

Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection
por: Cheung, King Yee, et al.
Publicado: (2021)

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury
por: Sevelsted Møller, Linda, et al.
Publicado: (2016)

KCa3.1 ion channel: A novel therapeutic target for corneal fibrosis
por: Anumanthan, Govindaraj, et al.
Publicado: (2018)

KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease
por: Huang, Chunling, et al.
Publicado: (2021)

Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes
por: Saxena, Sarah, et al.
Publicado: (2023)

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis
por: Lozano-Gerona, Javier, et al.
Publicado: (2020)

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma
por: Catacuzzeno, Luigi, et al.
Publicado: (2012)

KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells
por: Kuras, Zerrin, et al.
Publicado: (2012)

Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels
por: Lambertsen, Kate Lykke, et al.
Publicado: (2012)

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1
por: Ji, Tianyang, et al.
Publicado: (2018)

Functional Roles of the Ca(2+)-activated K(+) Channel, KCa3.1, in Brain Tumors
por: D’Alessandro, Giuseppina, et al.
Publicado: (2018)

Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1
por: Fei, Yu-Dong, et al.
Publicado: (2019)

Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice
por: Christensen, Inga B., et al.
Publicado: (2013)

Identifying SNAREs by Incorporating Deep Learning Architecture and Amino Acid Embedding Representation
por: Le, Nguyen Quoc Khanh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bou9lcpl223kl1k3d2h9k9h4os