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Acne exacerbation after tofacitinib treatment for alopecia areata

The major discovery of the novel therapeutic Janus kinase (JAK) inhibitors has been implicated in several dermatological diseases. Recently, studies have shown the efficacy and encouraging results of oral JAK inhibitors as a treatment for alopecia areata (AA). Due to the novelty of this treatment, p...

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Autores principales: Alharthi, Sawsan, Turkmani, Mohammed G., AlJasser, Mohammed I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272012/
https://www.ncbi.nlm.nih.gov/pubmed/35832266
http://dx.doi.org/10.4081/dr.2022.9396
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author Alharthi, Sawsan
Turkmani, Mohammed G.
AlJasser, Mohammed I.
author_facet Alharthi, Sawsan
Turkmani, Mohammed G.
AlJasser, Mohammed I.
author_sort Alharthi, Sawsan
collection PubMed
description The major discovery of the novel therapeutic Janus kinase (JAK) inhibitors has been implicated in several dermatological diseases. Recently, studies have shown the efficacy and encouraging results of oral JAK inhibitors as a treatment for alopecia areata (AA). Due to the novelty of this treatment, potential side effects are not fully explored. In this paper, we present a case of a 28-year-old male with a 10-year history of alopecia totalis (AT) treated successfully with tofacitinib with encouraging effects on hair regrowth; however, a significant worsening of the patient’s facial acne was observed four months after AT treatment initiation. JAK inhibitors have promising results in the management of different dermatological conditions including moderatesevere forms of AA with few reported adverse events. Acne exacerbation is a unique observed adverse effect of this therapy. More thorough larger sized studies are needed to further characterize the association between acne exacerbation and the use of JAK inhibitors.
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spelling pubmed-92720122022-07-12 Acne exacerbation after tofacitinib treatment for alopecia areata Alharthi, Sawsan Turkmani, Mohammed G. AlJasser, Mohammed I. Dermatol Reports Article The major discovery of the novel therapeutic Janus kinase (JAK) inhibitors has been implicated in several dermatological diseases. Recently, studies have shown the efficacy and encouraging results of oral JAK inhibitors as a treatment for alopecia areata (AA). Due to the novelty of this treatment, potential side effects are not fully explored. In this paper, we present a case of a 28-year-old male with a 10-year history of alopecia totalis (AT) treated successfully with tofacitinib with encouraging effects on hair regrowth; however, a significant worsening of the patient’s facial acne was observed four months after AT treatment initiation. JAK inhibitors have promising results in the management of different dermatological conditions including moderatesevere forms of AA with few reported adverse events. Acne exacerbation is a unique observed adverse effect of this therapy. More thorough larger sized studies are needed to further characterize the association between acne exacerbation and the use of JAK inhibitors. PAGEPress Publications, Pavia, Italy 2022-01-01 /pmc/articles/PMC9272012/ /pubmed/35832266 http://dx.doi.org/10.4081/dr.2022.9396 Text en ©Copyright: the Author(s) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Alharthi, Sawsan
Turkmani, Mohammed G.
AlJasser, Mohammed I.
Acne exacerbation after tofacitinib treatment for alopecia areata
title Acne exacerbation after tofacitinib treatment for alopecia areata
title_full Acne exacerbation after tofacitinib treatment for alopecia areata
title_fullStr Acne exacerbation after tofacitinib treatment for alopecia areata
title_full_unstemmed Acne exacerbation after tofacitinib treatment for alopecia areata
title_short Acne exacerbation after tofacitinib treatment for alopecia areata
title_sort acne exacerbation after tofacitinib treatment for alopecia areata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272012/
https://www.ncbi.nlm.nih.gov/pubmed/35832266
http://dx.doi.org/10.4081/dr.2022.9396
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