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The involvement of microRNAs in HCV and HIV infection

Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infect...

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Autores principales: Joshi, Nicky, Chandane Tak, Madhuri, Mukherjee, Anupam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272158/
https://www.ncbi.nlm.nih.gov/pubmed/35832725
http://dx.doi.org/10.1177/25151355221106104
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author Joshi, Nicky
Chandane Tak, Madhuri
Mukherjee, Anupam
author_facet Joshi, Nicky
Chandane Tak, Madhuri
Mukherjee, Anupam
author_sort Joshi, Nicky
collection PubMed
description Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in miRNA expression can lead to unfavorable outcomes; hence, this exact inevitable nature has made various studies a focal point. A considerable improvement in comprehending HIV and HCV mono-infection pathogenesis is seen using miRNAs. The prominent reason behind HIV/HCV co-infection is seen to be their standard route of transmission, while some pieces of evidence also suspect viral interplay between having a role in increased viral infection. This review highlights the involvement of microRNAs in HIV/HCV co-infection, along with their contribution in HIV mono- and HCV mono-infection. We also discuss miRNAs that carry the potentiality of becoming a biomarker for viral infection and early disease progression.
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spelling pubmed-92721582022-07-12 The involvement of microRNAs in HCV and HIV infection Joshi, Nicky Chandane Tak, Madhuri Mukherjee, Anupam Ther Adv Vaccines Immunother Review Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in miRNA expression can lead to unfavorable outcomes; hence, this exact inevitable nature has made various studies a focal point. A considerable improvement in comprehending HIV and HCV mono-infection pathogenesis is seen using miRNAs. The prominent reason behind HIV/HCV co-infection is seen to be their standard route of transmission, while some pieces of evidence also suspect viral interplay between having a role in increased viral infection. This review highlights the involvement of microRNAs in HIV/HCV co-infection, along with their contribution in HIV mono- and HCV mono-infection. We also discuss miRNAs that carry the potentiality of becoming a biomarker for viral infection and early disease progression. SAGE Publications 2022-07-05 /pmc/articles/PMC9272158/ /pubmed/35832725 http://dx.doi.org/10.1177/25151355221106104 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Joshi, Nicky
Chandane Tak, Madhuri
Mukherjee, Anupam
The involvement of microRNAs in HCV and HIV infection
title The involvement of microRNAs in HCV and HIV infection
title_full The involvement of microRNAs in HCV and HIV infection
title_fullStr The involvement of microRNAs in HCV and HIV infection
title_full_unstemmed The involvement of microRNAs in HCV and HIV infection
title_short The involvement of microRNAs in HCV and HIV infection
title_sort involvement of micrornas in hcv and hiv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272158/
https://www.ncbi.nlm.nih.gov/pubmed/35832725
http://dx.doi.org/10.1177/25151355221106104
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