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METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma

BACKGROUND: Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents. The molecular mechanism behind OS progression and metastasis remains poorly understood, which limits the effectiveness of current therapies. RNA N(6)-methyladenosine (m(6)A) modification plays a critical ro...

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Detalles Bibliográficos
Autores principales:	Li, Hong-Bo, Huang, Gang, Tu, Jian, Lv, Dong-Ming, Jin, Qing-Lin, Chen, Jun-Kai, Zou, Yu-Tong, Lee, Dung-Fang, Shen, Jing-Nan, Xie, Xian-Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272358/ https://www.ncbi.nlm.nih.gov/pubmed/35810559 http://dx.doi.org/10.1016/j.ebiom.2022.104142

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