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Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations
The phenotypic diversity of African cattle reflects adaptation to a wide range of agroecological conditions, human-mediated selection preferences, and complex patterns of admixture between the humpless Bos taurus (taurine) and humped Bos indicus (zebu) subspecies, which diverged 150–500 thousand yea...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272374/ https://www.ncbi.nlm.nih.gov/pubmed/35832892 http://dx.doi.org/10.1016/j.isci.2022.104672 |
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author | Ward, James A. McHugo, Gillian P. Dover, Michael J. Hall, Thomas J. Ng'ang'a, Said Ismael Sonstegard, Tad S. Bradley, Daniel G. Frantz, Laurent A.F. Salter-Townshend, Michael MacHugh, David E. |
author_facet | Ward, James A. McHugo, Gillian P. Dover, Michael J. Hall, Thomas J. Ng'ang'a, Said Ismael Sonstegard, Tad S. Bradley, Daniel G. Frantz, Laurent A.F. Salter-Townshend, Michael MacHugh, David E. |
author_sort | Ward, James A. |
collection | PubMed |
description | The phenotypic diversity of African cattle reflects adaptation to a wide range of agroecological conditions, human-mediated selection preferences, and complex patterns of admixture between the humpless Bos taurus (taurine) and humped Bos indicus (zebu) subspecies, which diverged 150–500 thousand years ago. Despite extensive admixture, all African cattle possess taurine mitochondrial haplotypes, even populations with significant zebu biparental and male uniparental nuclear ancestry. This has been interpreted as the result of human-mediated dispersal ultimately stemming from zebu bulls imported from South Asia during the last three millennia. Here, we assess whether ancestry at mitochondrially targeted nuclear genes in African admixed cattle is impacted by mitonuclear functional interactions. Using high-density SNP data, we find evidence for mitonuclear coevolution across hybrid African cattle populations with a significant increase of taurine ancestry at mitochondrially targeted nuclear genes. Our results, therefore, support the hypothesis of incompatibility between the taurine mitochondrial genome and the zebu nuclear genome. |
format | Online Article Text |
id | pubmed-9272374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92723742022-07-12 Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations Ward, James A. McHugo, Gillian P. Dover, Michael J. Hall, Thomas J. Ng'ang'a, Said Ismael Sonstegard, Tad S. Bradley, Daniel G. Frantz, Laurent A.F. Salter-Townshend, Michael MacHugh, David E. iScience Article The phenotypic diversity of African cattle reflects adaptation to a wide range of agroecological conditions, human-mediated selection preferences, and complex patterns of admixture between the humpless Bos taurus (taurine) and humped Bos indicus (zebu) subspecies, which diverged 150–500 thousand years ago. Despite extensive admixture, all African cattle possess taurine mitochondrial haplotypes, even populations with significant zebu biparental and male uniparental nuclear ancestry. This has been interpreted as the result of human-mediated dispersal ultimately stemming from zebu bulls imported from South Asia during the last three millennia. Here, we assess whether ancestry at mitochondrially targeted nuclear genes in African admixed cattle is impacted by mitonuclear functional interactions. Using high-density SNP data, we find evidence for mitonuclear coevolution across hybrid African cattle populations with a significant increase of taurine ancestry at mitochondrially targeted nuclear genes. Our results, therefore, support the hypothesis of incompatibility between the taurine mitochondrial genome and the zebu nuclear genome. Elsevier 2022-06-26 /pmc/articles/PMC9272374/ /pubmed/35832892 http://dx.doi.org/10.1016/j.isci.2022.104672 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ward, James A. McHugo, Gillian P. Dover, Michael J. Hall, Thomas J. Ng'ang'a, Said Ismael Sonstegard, Tad S. Bradley, Daniel G. Frantz, Laurent A.F. Salter-Townshend, Michael MacHugh, David E. Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title | Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title_full | Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title_fullStr | Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title_full_unstemmed | Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title_short | Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations |
title_sort | genome-wide local ancestry and evidence for mitonuclear coadaptation in african hybrid cattle populations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272374/ https://www.ncbi.nlm.nih.gov/pubmed/35832892 http://dx.doi.org/10.1016/j.isci.2022.104672 |
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