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Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review

Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in glo...

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Autores principales: Kijpornyongpan, Teeratas, Schwartz, Alexa, Yaguchi, Allison, Salvachúa, Davinia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272384/
https://www.ncbi.nlm.nih.gov/pubmed/35832889
http://dx.doi.org/10.1016/j.isci.2022.104640
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author Kijpornyongpan, Teeratas
Schwartz, Alexa
Yaguchi, Allison
Salvachúa, Davinia
author_facet Kijpornyongpan, Teeratas
Schwartz, Alexa
Yaguchi, Allison
Salvachúa, Davinia
author_sort Kijpornyongpan, Teeratas
collection PubMed
description Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in global carbon cycling and highlights their potential utilization in diverse biotechnological applications. To date, research on WRF has primarily focused on their extracellular ‘digestive enzymes’ whereas knowledge of their intracellular metabolism remains underexplored. Systems biology is a powerful approach to elucidate biological processes in numerous organisms, including WRF. Thus, here we review systems biology methods applied to WRF to date, highlight observations related to their intracellular metabolism, and conduct comparative extracellular proteomic analyses to establish further correlations between WRF species, enzymes, and cultivation conditions. Lastly, we discuss biotechnological opportunities of WRF as well as challenges and future research directions.
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spelling pubmed-92723842022-07-12 Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review Kijpornyongpan, Teeratas Schwartz, Alexa Yaguchi, Allison Salvachúa, Davinia iScience Review Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in global carbon cycling and highlights their potential utilization in diverse biotechnological applications. To date, research on WRF has primarily focused on their extracellular ‘digestive enzymes’ whereas knowledge of their intracellular metabolism remains underexplored. Systems biology is a powerful approach to elucidate biological processes in numerous organisms, including WRF. Thus, here we review systems biology methods applied to WRF to date, highlight observations related to their intracellular metabolism, and conduct comparative extracellular proteomic analyses to establish further correlations between WRF species, enzymes, and cultivation conditions. Lastly, we discuss biotechnological opportunities of WRF as well as challenges and future research directions. Elsevier 2022-06-18 /pmc/articles/PMC9272384/ /pubmed/35832889 http://dx.doi.org/10.1016/j.isci.2022.104640 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Kijpornyongpan, Teeratas
Schwartz, Alexa
Yaguchi, Allison
Salvachúa, Davinia
Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title_full Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title_fullStr Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title_full_unstemmed Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title_short Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
title_sort systems biology-guided understanding of white-rot fungi for biotechnological applications: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272384/
https://www.ncbi.nlm.nih.gov/pubmed/35832889
http://dx.doi.org/10.1016/j.isci.2022.104640
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