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Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review
Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in glo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272384/ https://www.ncbi.nlm.nih.gov/pubmed/35832889 http://dx.doi.org/10.1016/j.isci.2022.104640 |
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author | Kijpornyongpan, Teeratas Schwartz, Alexa Yaguchi, Allison Salvachúa, Davinia |
author_facet | Kijpornyongpan, Teeratas Schwartz, Alexa Yaguchi, Allison Salvachúa, Davinia |
author_sort | Kijpornyongpan, Teeratas |
collection | PubMed |
description | Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in global carbon cycling and highlights their potential utilization in diverse biotechnological applications. To date, research on WRF has primarily focused on their extracellular ‘digestive enzymes’ whereas knowledge of their intracellular metabolism remains underexplored. Systems biology is a powerful approach to elucidate biological processes in numerous organisms, including WRF. Thus, here we review systems biology methods applied to WRF to date, highlight observations related to their intracellular metabolism, and conduct comparative extracellular proteomic analyses to establish further correlations between WRF species, enzymes, and cultivation conditions. Lastly, we discuss biotechnological opportunities of WRF as well as challenges and future research directions. |
format | Online Article Text |
id | pubmed-9272384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92723842022-07-12 Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review Kijpornyongpan, Teeratas Schwartz, Alexa Yaguchi, Allison Salvachúa, Davinia iScience Review Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in global carbon cycling and highlights their potential utilization in diverse biotechnological applications. To date, research on WRF has primarily focused on their extracellular ‘digestive enzymes’ whereas knowledge of their intracellular metabolism remains underexplored. Systems biology is a powerful approach to elucidate biological processes in numerous organisms, including WRF. Thus, here we review systems biology methods applied to WRF to date, highlight observations related to their intracellular metabolism, and conduct comparative extracellular proteomic analyses to establish further correlations between WRF species, enzymes, and cultivation conditions. Lastly, we discuss biotechnological opportunities of WRF as well as challenges and future research directions. Elsevier 2022-06-18 /pmc/articles/PMC9272384/ /pubmed/35832889 http://dx.doi.org/10.1016/j.isci.2022.104640 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Kijpornyongpan, Teeratas Schwartz, Alexa Yaguchi, Allison Salvachúa, Davinia Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title | Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title_full | Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title_fullStr | Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title_full_unstemmed | Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title_short | Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review |
title_sort | systems biology-guided understanding of white-rot fungi for biotechnological applications: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272384/ https://www.ncbi.nlm.nih.gov/pubmed/35832889 http://dx.doi.org/10.1016/j.isci.2022.104640 |
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