Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?

The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in chi...

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Autores principales: Tobin, Nicole H, Yang, Otto O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272428/
https://www.ncbi.nlm.nih.gov/pubmed/35821728
http://dx.doi.org/10.1093/ofid/ofac222
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author Tobin, Nicole H
Yang, Otto O
author_facet Tobin, Nicole H
Yang, Otto O
author_sort Tobin, Nicole H
collection PubMed
description The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward.
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spelling pubmed-92724282022-07-11 Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More? Tobin, Nicole H Yang, Otto O Open Forum Infect Dis Perspectives The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward. Oxford University Press 2022-05-01 /pmc/articles/PMC9272428/ /pubmed/35821728 http://dx.doi.org/10.1093/ofid/ofac222 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Perspectives
Tobin, Nicole H
Yang, Otto O
Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title_full Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title_fullStr Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title_full_unstemmed Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title_short Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
title_sort coronavirus disease 2019 vaccine dosage in children, adolescents, and young adults: is less more?
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272428/
https://www.ncbi.nlm.nih.gov/pubmed/35821728
http://dx.doi.org/10.1093/ofid/ofac222
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