Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in a severe pneumonia associated with elevation of blood inflammatory parameters, reminiscent of cytokine storm syndrome. Steroidal anti-inflammatory therapies have shown efficacy in reducing mortality in c...

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Detalles Bibliográficos
Autores principales: Bertoni, Arinna, Penco, Federica, Mollica, Hilaria, Bocca, Paola, Prigione, Ignazia, Corcione, Anna, Cangelosi, Davide, Schena, Francesca, Del Zotto, Genny, Amaro, Adriana, Paladino, Noemi, Pontali, Emanuele, Feasi, Marcello, Signa, Sara, Bustaffa, Marta, Caorsi, Roberta, Palmeri, Serena, Contini, Paola, De Palma, Raffaele, Pfeffer, Ulrich, Uva, Paolo, Rubartelli, Anna, Gattorno, Marco, Volpi, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology 2022
Materias:
Covid-19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272569/
https://www.ncbi.nlm.nih.gov/pubmed/35835255
http://dx.doi.org/10.1016/j.jaci.2022.05.029

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