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Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants

Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent spike (S) and nucleocapsid (N) antigen-specific humoral and...

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Detalles Bibliográficos
Autores principales:	Chiuppesi, Flavia, Zaia, John A., Faircloth, Katelyn, Johnson, Daisy, Ly, Minh, Karpinski, Veronica, La Rosa, Corinna, Drake, Jennifer, Marcia, Joan, Acosta, Ann Marie, Dempsey, Shannon, Taplitz, Randy A., Zhou, Qiao, Park, Yoonsuh, Ortega Francisco, Sandra, Kaltcheva, Teodora, Frankel, Paul H., Rosen, Steven, Wussow, Felix, Dadwal, Sanjeet, Diamond, Don J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272674/ https://www.ncbi.nlm.nih.gov/pubmed/35846380 http://dx.doi.org/10.1016/j.isci.2022.104745

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