Cargando…

Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone

Coronavirus disease 2019 (COVID-19) is a global pandemic and respiratory infection that has enormous damage to human lives and economies. It is caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a non-pair-stranded positive-sense RNA virus. With increasing global threats and few...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lawal, Bashir, Kuo, Yu-Cheng, Rachmawati Sumitra, Maryam, Wu, Alexander T.H., Huang, Hsu-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272679/ https://www.ncbi.nlm.nih.gov/pubmed/35841781 http://dx.doi.org/10.1016/j.compbiomed.2022.105814

Ejemplares similares

In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents
por: Chen, Yi-Fong, et al.
Publicado: (2023)

In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer
por: Lawal, Bashir, et al.
Publicado: (2021)

Chemical reaction network knowledge graphs: the OntoRXN ontology
por: Garay-Ruiz, Diego, et al.
Publicado: (2022)

An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3β/β-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties
por: Mokgautsi, Ntlotlang, et al.
Publicado: (2021)

Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types
por: Mokgautsi, Ntlotlang, et al.
Publicado: (2021)

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications
por: Lawal, Bashir, et al.
Publicado: (2021)

MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases
por: Kumar, Akhil, et al.
Publicado: (2012)

In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1
por: Khedkar, Harshita Nivrutti, et al.
Publicado: (2021)

Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines
por: Lawal, Bashir, et al.
Publicado: (2021)

In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates
por: Lawal, Bashir, et al.
Publicado: (2023)

Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule
por: Lawal, Bashir, et al.
Publicado: (2022)

Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin
por: Kocsis, Bela, et al.
Publicado: (2016)

LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells
por: Angom, Ramcharan Singh, et al.
Publicado: (2021)

A Novel Isotope-labeled Small Molecule Probe CC12 for Anti-glioma via Suppressing LYN-mediated Progression and Activating Apoptosis Pathways
por: Huang, Hsu-Shan, et al.
Publicado: (2023)

Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation
por: Yadav, Vijesh Kumar, et al.
Publicado: (2020)

Novel Quinolone Derivatives: Synthesis and Antioxidant Activity
por: Prasad, Mutyala Veera Venkata Vara, et al.
Publicado: (2022)

Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia
por: Torres-Fuentes, Cristina, et al.
Publicado: (2018)

HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses
por: Lee, Jih-Chin, et al.
Publicado: (2020)

Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative
por: Wu, Alexander T. H., et al.
Publicado: (2022)

Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules
por: Fedorowicz, Joanna, et al.
Publicado: (2018)

Preclinical Evaluation of a Novel Small Molecule LCC-21 to Suppress Colorectal Cancer Malignancy by Inhibiting Angiogenic and Metastatic Signatures
por: Mokgautsi, Ntlotlang, et al.
Publicado: (2023)

Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent
por: Mukherjee, Suprabhat, et al.
Publicado: (2018)

Synthesis and Antimicrobial Activity of Novel 4-Hydroxy-2-quinolone Analogs
por: Khamkhenshorngphanuch, Thitiphong, et al.
Publicado: (2020)

In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone
por: Roychoudhury, Siddhartha, et al.
Publicado: (2016)

Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration
por: Lawal, Bashir, et al.
Publicado: (2021)

Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
por: Dubal, G. G., et al.
Publicado: (2022)

Quinolone Allergy
por: McGee, Edoabasi U., et al.
Publicado: (2019)

Quinolone antibiotics
por: Pham, Thu D. M., et al.
Publicado: (2019)

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models
por: Gravina, Giovanni Luca, et al.
Publicado: (2017)

Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
por: Díaz, Iván, et al.
Publicado: (2022)

Surface-Growing Communities of Pseudomonas aeruginosa Exhibit Distinct Alkyl Quinolone Signatures
por: Morales-Soto, Nydia, et al.
Publicado: (2018)

Synthesis of Quinolones and Zwitterionic Quinolonate Derivatives with Broad-Spectrum Antibiotic Activity
por: Suay-García, Beatriz, et al.
Publicado: (2022)

Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.
por: Paulsen, Sara Skøtt, et al.
Publicado: (2020)

Quinolone Safety and Efficacy
por: Bellomo, Spartaco
Publicado: (2005)

Comprehensive Omics Analysis of a Novel Small-Molecule Inhibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects
por: Huang, Tse-Hung, et al.
Publicado: (2021)

Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
por: Gorelenkova Miller, Olga, et al.
Publicado: (2017)

Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives
por: Lawal, Bashir, et al.
Publicado: (2021)

Anti-inflammatory effects of ozenoxacin, a topical quinolone antimicrobial agent
por: Tabara, Keisuke, et al.
Publicado: (2020)

Quinolone Resistance in Gallibacterium anatis Determined by Mutations in Quinolone Resistance-Determining Region
por: Rømer Villumsen, Kasper, et al.
Publicado: (2023)

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent
por: Chinyama, Harold A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lj1k2ptotpperb3pvosm90qi9u