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Tacrolimus CYP3A Single-Nucleotide Polymorphisms and Preformed T- and B-Cell Alloimmune Memory Improve Current Pretransplant Rejection-Risk Stratification in Kidney Transplantation

Achieving fast immunosuppression blood exposure after kidney transplantation is key to abrogating both preformed and de novo anti-donor humoral and cellular alloresponses. However, while tacrolimus (TAC) is the cornerstone immunosuppressant inhibiting adaptive alloimmunity, its blood exposure is dir...

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Detalles Bibliográficos
Autores principales:	Crespo, Elena, Vidal-Alabró, Anna, Jouve, Thomas, Fontova, Pere, Stein, Maik, Mocka, Sonila, Meneghini, Maria, Sefrin, Anett, Hruba, Petra, Gomà, Montserrat, Torija, Alba, Donadeu, Laura, Favà, Alex, Cruzado, Josep M., Melilli, Edoardo, Moreso, Francesc, Viklicky, Ondrej, Bemelman, Frederike, Reinke, Petra, Grinyó, Josep, Lloberas, Nuria, Bestard, Oriol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272702/ https://www.ncbi.nlm.nih.gov/pubmed/35833145 http://dx.doi.org/10.3389/fimmu.2022.869554

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