18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom

Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomo...

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Autores principales: Tang, Songhan, Dou, Xiaofeng, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272837/
https://www.ncbi.nlm.nih.gov/pubmed/35801711
http://dx.doi.org/10.1080/19336896.2022.2093078
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author Tang, Songhan
Dou, Xiaofeng
Zhang, Ying
author_facet Tang, Songhan
Dou, Xiaofeng
Zhang, Ying
author_sort Tang, Songhan
collection PubMed
description Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD.
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spelling pubmed-92728372022-07-12 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom Tang, Songhan Dou, Xiaofeng Zhang, Ying Prion Case Report Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD. Taylor & Francis 2022-07-08 /pmc/articles/PMC9272837/ /pubmed/35801711 http://dx.doi.org/10.1080/19336896.2022.2093078 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tang, Songhan
Dou, Xiaofeng
Zhang, Ying
18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title_full 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title_fullStr 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title_full_unstemmed 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title_short 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
title_sort 18f-fp-cit pet/ct in a case of probable sporadic creutzfeldt-jakob disease with parkinsonism as initial symptom
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272837/
https://www.ncbi.nlm.nih.gov/pubmed/35801711
http://dx.doi.org/10.1080/19336896.2022.2093078
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AT zhangying 18ffpcitpetctinacaseofprobablesporadiccreutzfeldtjakobdiseasewithparkinsonismasinitialsymptom

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