Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

A new series of 1H-pyrrole (6a–c, 8a–c), pyrrolo[3,2-d]pyrimidines (9a–c) and pyrrolo[3,2-e][1, 4]diazepines (11a–c) were designed and synthesised. These compounds were designed to have the essential pharmacophoric features of EGFR Inhibitors, they have shown anticancer activities against HCT116, MC...

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Detalles Bibliográficos
Autores principales: Belal, Amany, Abdel Gawad, Nagwa M., Mehany, Ahmed B. M., Abourehab, Mohammed A. S., Elkady, Hazem, Al‐Karmalawy, Ahmed A., Ismael, Ahmed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272933/
https://www.ncbi.nlm.nih.gov/pubmed/35801486
http://dx.doi.org/10.1080/14756366.2022.2096019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272933/
https://www.ncbi.nlm.nih.gov/pubmed/35801486
http://dx.doi.org/10.1080/14756366.2022.2096019

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