Oxaliplatin reacts with DMSO only in the presence of water

Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(ii) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR a...

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Autores principales: Varbanov, Hristo P., Ortiz, Daniel, Höfer, Doris, Menin, Laure, Galanski, Mathea S., Keppler, Bernhard K., Dyson, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272996/
https://www.ncbi.nlm.nih.gov/pubmed/28654098
http://dx.doi.org/10.1039/c7dt01628j
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author Varbanov, Hristo P.
Ortiz, Daniel
Höfer, Doris
Menin, Laure
Galanski, Mathea S.
Keppler, Bernhard K.
Dyson, Paul J.
author_facet Varbanov, Hristo P.
Ortiz, Daniel
Höfer, Doris
Menin, Laure
Galanski, Mathea S.
Keppler, Bernhard K.
Dyson, Paul J.
author_sort Varbanov, Hristo P.
collection PubMed
description Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(ii) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques.
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spelling pubmed-92729962022-08-01 Oxaliplatin reacts with DMSO only in the presence of water Varbanov, Hristo P. Ortiz, Daniel Höfer, Doris Menin, Laure Galanski, Mathea S. Keppler, Bernhard K. Dyson, Paul J. Dalton Trans Chemistry Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(ii) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques. The Royal Society of Chemistry 2017-06-27 /pmc/articles/PMC9272996/ /pubmed/28654098 http://dx.doi.org/10.1039/c7dt01628j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Varbanov, Hristo P.
Ortiz, Daniel
Höfer, Doris
Menin, Laure
Galanski, Mathea S.
Keppler, Bernhard K.
Dyson, Paul J.
Oxaliplatin reacts with DMSO only in the presence of water
title Oxaliplatin reacts with DMSO only in the presence of water
title_full Oxaliplatin reacts with DMSO only in the presence of water
title_fullStr Oxaliplatin reacts with DMSO only in the presence of water
title_full_unstemmed Oxaliplatin reacts with DMSO only in the presence of water
title_short Oxaliplatin reacts with DMSO only in the presence of water
title_sort oxaliplatin reacts with dmso only in the presence of water
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272996/
https://www.ncbi.nlm.nih.gov/pubmed/28654098
http://dx.doi.org/10.1039/c7dt01628j
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