Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies. These substitutions could also shape future evolution by modulating the effects of mutations at other sites—a phenomenon called epis...

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Detalles Bibliográficos
Autores principales: Starr, Tyler N., Greaney, Allison J., Hannon, William W., Loes, Andrea N., Hauser, Kevin, Dillen, Josh R., Ferri, Elena, Farrell, Ariana Ghez, Dadonaite, Bernadeta, McCallum, Matthew, Matreyek, Kenneth A., Corti, Davide, Veesler, David, Snell, Gyorgy, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273037/
https://www.ncbi.nlm.nih.gov/pubmed/35762884
http://dx.doi.org/10.1126/science.abo7896

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