Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer

As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung damage caused by deregulated signaling in the renin-an...

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Detalles Bibliográficos
Autores principales: Shoemaker, Robert H., Panettieri, Reynold A., Libutti, Steven K., Hochster, Howard S., Watts, Norman R., Wingfield, Paul T., Starkl, Philipp, Pimenov, Lisabeth, Gawish, Riem, Hladik, Anastasiya, Knapp, Sylvia, Boring, Daniel, White, Jonathan M., Lawrence, Quentin, Boone, Jeremy, Marshall, Jason D., Matthews, Rebecca L., Cholewa, Brian D., Richig, Jeffrey W., Chen, Ben T., McCormick, David L., Gugensberger, Romana, Höller, Sonja, Penninger, Josef M., Wirnsberger, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273060/
https://www.ncbi.nlm.nih.gov/pubmed/35816490
http://dx.doi.org/10.1371/journal.pone.0271066

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