A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was generated from an HCV infected liver-transplanted...

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Detalles Bibliográficos
Autores principales: Heuss, Christian, Rothhaar, Paul, Burm, Rani, Lee, Ji-Young, Ralfs, Philipp, Haselmann, Uta, Ströh, Luisa J., Colasanti, Ombretta, Tran, Cong Si, Schäfer, Noemi, Schnitzler, Paul, Merle, Uta, Bartenschlager, Ralf, Patel, Arvind H., Graw, Frederik, Krey, Thomas, Laketa, Vibor, Meuleman, Philip, Lohmann, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273080/
https://www.ncbi.nlm.nih.gov/pubmed/35763545
http://dx.doi.org/10.1371/journal.ppat.1010472

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