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Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature
OBJECTIVE: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. DATA SOURCE: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade de Pediatria de São Paulo
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273119/ https://www.ncbi.nlm.nih.gov/pubmed/35830160 http://dx.doi.org/10.1590/1984-0462/2023/41/2021197 |
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author | Moreira, Gabriela Araujo Moraes, Roddie Ribeiro, Ricardo Gullit Crippa, Ana Chrystina De Souza |
author_facet | Moreira, Gabriela Araujo Moraes, Roddie Ribeiro, Ricardo Gullit Crippa, Ana Chrystina De Souza |
author_sort | Moreira, Gabriela Araujo |
collection | PubMed |
description | OBJECTIVE: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. DATA SOURCE: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online (SciELO) databases with the descriptors “Cannabidiol” and “Epilepsy.” The search was not limited by the date of publication, language, or study design. A total of 69 articles were included in the review. DATA SYNTHESIS: The efficacy of CBD in treating epileptic seizures has been confirmed by randomized controlled trials for Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. The incidence of side effects reported in subjects of the studies is high. However, most studies indicate a good safety profile and tolerance to the drug, with most of the adverse effects being mild to moderate and transient. CONCLUSIONS: There is no consensus on the release of CBD as a therapeutic tool by the drug regulatory agencies worldwide. However, the use of CBD is promising since it has presented satisfactory results in crisis control in well-designed studies. In addition, this drug has a good safety and tolerance profile. However, further studies with a long follow-up period are needed to confirm its usefulness and the long-term safety in pediatric patients. |
format | Online Article Text |
id | pubmed-9273119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade de Pediatria de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-92731192022-07-22 Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature Moreira, Gabriela Araujo Moraes, Roddie Ribeiro, Ricardo Gullit Crippa, Ana Chrystina De Souza Rev Paul Pediatr Review Article OBJECTIVE: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. DATA SOURCE: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online (SciELO) databases with the descriptors “Cannabidiol” and “Epilepsy.” The search was not limited by the date of publication, language, or study design. A total of 69 articles were included in the review. DATA SYNTHESIS: The efficacy of CBD in treating epileptic seizures has been confirmed by randomized controlled trials for Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. The incidence of side effects reported in subjects of the studies is high. However, most studies indicate a good safety profile and tolerance to the drug, with most of the adverse effects being mild to moderate and transient. CONCLUSIONS: There is no consensus on the release of CBD as a therapeutic tool by the drug regulatory agencies worldwide. However, the use of CBD is promising since it has presented satisfactory results in crisis control in well-designed studies. In addition, this drug has a good safety and tolerance profile. However, further studies with a long follow-up period are needed to confirm its usefulness and the long-term safety in pediatric patients. Sociedade de Pediatria de São Paulo 2022-07-06 /pmc/articles/PMC9273119/ /pubmed/35830160 http://dx.doi.org/10.1590/1984-0462/2023/41/2021197 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Review Article Moreira, Gabriela Araujo Moraes, Roddie Ribeiro, Ricardo Gullit Crippa, Ana Chrystina De Souza Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title | Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_full | Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_fullStr | Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_full_unstemmed | Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_short | Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_sort | cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273119/ https://www.ncbi.nlm.nih.gov/pubmed/35830160 http://dx.doi.org/10.1590/1984-0462/2023/41/2021197 |
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