Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, Pnpla2 gene). BMAd-Pnpla2(-/-) mice have impaired BMAd lipolysis, and increased size and number of BMAds at basel...

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Detalles Bibliográficos
Autores principales: Li, Ziru, Bowers, Emily, Zhu, Junxiong, Yu, Hui, Hardij, Julie, Bagchi, Devika P, Mori, Hiroyuki, Lewis, Kenneth T, Granger, Katrina, Schill, Rebecca L, Romanelli, Steven M, Abrishami, Simin, Hankenson, Kurt D, Singer, Kanakadurga, Rosen, Clifford J, MacDougald, Ormond A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273217/
https://www.ncbi.nlm.nih.gov/pubmed/35731039
http://dx.doi.org/10.7554/eLife.78496

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