Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect

A significant challenge to making targeted cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies accessible to all individuals with cystic fibrosis (CF) are many mutations in the CFTR gene that can cause CF, most of which remain uncharacterized. Here, we characterized the st...

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Detalles Bibliográficos
Autores principales: Wong, Sharon L., Awatade, Nikhil T., Astore, Miro A., Allan, Katelin M., Carnell, Michael J., Slapetova, Iveta, Chen, Po-chia, Setiadi, Jeffry, Pandzic, Elvis, Fawcett, Laura K., Widger, John R., Whan, Renee M., Griffith, Renate, Ooi, Chee Y., Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273222/
https://www.ncbi.nlm.nih.gov/pubmed/35471184
http://dx.doi.org/10.1165/rcmb.2021-0337OC

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