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Modern drug discovery applications for the identification of novel candidates for COVID-19 infections

In early December 2019, a large pneumonia epidemic occurred in Wuhan, China. The World Health Organization is concerned about the outbreak of another coronavirus with the powerful, rapid, and contagious transmission. Anyone with minor symptoms like fever and cough or travel history to contaminated p...

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Autores principales: Rani, Isha, Kalsi, Avjit, Kaur, Gagandeep, Sharma, Pankaj, Gupta, Sumeet, Gautam, Rupesh K., Chopra, Hitesh, Bibi, Shabana, Ahmad, Syed Umair, Singh, Inderbir, Dhawan, Manish, Emran, Talha Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273307/
https://www.ncbi.nlm.nih.gov/pubmed/35845863
http://dx.doi.org/10.1016/j.amsu.2022.104125
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author Rani, Isha
Kalsi, Avjit
Kaur, Gagandeep
Sharma, Pankaj
Gupta, Sumeet
Gautam, Rupesh K.
Chopra, Hitesh
Bibi, Shabana
Ahmad, Syed Umair
Singh, Inderbir
Dhawan, Manish
Emran, Talha Bin
author_facet Rani, Isha
Kalsi, Avjit
Kaur, Gagandeep
Sharma, Pankaj
Gupta, Sumeet
Gautam, Rupesh K.
Chopra, Hitesh
Bibi, Shabana
Ahmad, Syed Umair
Singh, Inderbir
Dhawan, Manish
Emran, Talha Bin
author_sort Rani, Isha
collection PubMed
description In early December 2019, a large pneumonia epidemic occurred in Wuhan, China. The World Health Organization is concerned about the outbreak of another coronavirus with the powerful, rapid, and contagious transmission. Anyone with minor symptoms like fever and cough or travel history to contaminated places might be suspected of having COVID-19. COVID-19 therapy focuses on treating the disease's symptoms. So far, no such therapeutic molecule has been shown effective in treating this condition. So the treatment is mostly supportive and plasma. Globally, numerous studies and researchers have recently started fighting this virus. Vaccines and chemical compounds are also being investigated against infection. COVID-19 was successfully diagnosed using RNA detection and very sensitive RT-PCR (reverse transcription-polymerase chain reaction). The evolution of particular vaccinations is required to reduce illness severity and spread. Numerous computational analyses and molecular docking have predicted various target compounds that might stop this condition. This paper examines the main characteristics of coronavirus and the computational analyses necessary to avoid infection.
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spelling pubmed-92733072022-07-12 Modern drug discovery applications for the identification of novel candidates for COVID-19 infections Rani, Isha Kalsi, Avjit Kaur, Gagandeep Sharma, Pankaj Gupta, Sumeet Gautam, Rupesh K. Chopra, Hitesh Bibi, Shabana Ahmad, Syed Umair Singh, Inderbir Dhawan, Manish Emran, Talha Bin Ann Med Surg (Lond) Review In early December 2019, a large pneumonia epidemic occurred in Wuhan, China. The World Health Organization is concerned about the outbreak of another coronavirus with the powerful, rapid, and contagious transmission. Anyone with minor symptoms like fever and cough or travel history to contaminated places might be suspected of having COVID-19. COVID-19 therapy focuses on treating the disease's symptoms. So far, no such therapeutic molecule has been shown effective in treating this condition. So the treatment is mostly supportive and plasma. Globally, numerous studies and researchers have recently started fighting this virus. Vaccines and chemical compounds are also being investigated against infection. COVID-19 was successfully diagnosed using RNA detection and very sensitive RT-PCR (reverse transcription-polymerase chain reaction). The evolution of particular vaccinations is required to reduce illness severity and spread. Numerous computational analyses and molecular docking have predicted various target compounds that might stop this condition. This paper examines the main characteristics of coronavirus and the computational analyses necessary to avoid infection. Elsevier 2022-07-12 /pmc/articles/PMC9273307/ /pubmed/35845863 http://dx.doi.org/10.1016/j.amsu.2022.104125 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rani, Isha
Kalsi, Avjit
Kaur, Gagandeep
Sharma, Pankaj
Gupta, Sumeet
Gautam, Rupesh K.
Chopra, Hitesh
Bibi, Shabana
Ahmad, Syed Umair
Singh, Inderbir
Dhawan, Manish
Emran, Talha Bin
Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title_full Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title_fullStr Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title_full_unstemmed Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title_short Modern drug discovery applications for the identification of novel candidates for COVID-19 infections
title_sort modern drug discovery applications for the identification of novel candidates for covid-19 infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273307/
https://www.ncbi.nlm.nih.gov/pubmed/35845863
http://dx.doi.org/10.1016/j.amsu.2022.104125
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