Cargando…

Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins

BMPs (bone morphogenetic proteins) are multipurpose (transforming growth factor)TGF-superfamily released cytokines. These glycoproteins, acting as disulfide-linked homo- or heterodimers, are highly potent regulators of bone and cartilage production and repair, cell proliferation throughout embryonic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmad, Hafiz Ishfaq, Ijaz, Nabeel, Afzal, Gulnaz, Asif, Akhtar Rasool, ur Rehman, Aziz, Rahman, Abdur, Ahmed, Irfan, Yousaf, Muhammad, Elokil, Abdelmotaleb, Muhammad, Sayyed Aun, Albogami, Sarah M., Alotaibi, Saqer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273450/ https://www.ncbi.nlm.nih.gov/pubmed/35832847 http://dx.doi.org/10.1155/2022/4013729

Ejemplares similares

A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
por: Girmay, Shishay, et al.
Publicado: (2022)

GESPA: classifying nsSNPs to predict disease association
por: Khurana, Jay K., et al.
Publicado: (2015)

Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
por: Dobson, Richard J, et al.
Publicado: (2006)

coliSNP database server mapping nsSNPs on protein structures
por: Kono, Hidetoshi, et al.
Publicado: (2008)

Investigation on the role of nsSNPs in HNPCC genes – a bioinformatics approach
por: Doss, C George Priya, et al.
Publicado: (2009)

An ANN model for the identification of deleterious nsSNPs in tumor suppressor genes
por: Chandra, Vinod, et al.
Publicado: (2011)

In-Silico Computing of the Most Deleterious nsSNPs in HBA1 Gene
por: AbdulAzeez, Sayed, et al.
Publicado: (2016)

Identification and analysis of pathogenic nsSNPs in human LSP1 gene
por: Ali, Hani Mohammed
Publicado: (2019)

In Silico Analysis Identified Putative Pathogenic Missense nsSNPs in Human SLITRK1 Gene
por: Ali, Muhammad Zeeshan, et al.
Publicado: (2022)

Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes
por: Azmi, Muhammad Bilal, et al.
Publicado: (2023)

Prediction and Experimental Characterization of nsSNPs Altering Human PDZ-Binding Motifs
por: Gfeller, David, et al.
Publicado: (2014)

Exploring the effect of nsSNPs in human YPEL3 gene in cellular senescence
por: Singh, Abhishek, et al.
Publicado: (2020)

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays
por: Khoruddin, Nurul Ain, et al.
Publicado: (2021)

Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1
por: Choudhury, Arunabh, et al.
Publicado: (2021)

Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs
por: Savas, Sevtap, et al.
Publicado: (2005)

Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome
por: Theodoratou, Evropi, et al.
Publicado: (2018)

Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference
por: Nawar, Noshin, et al.
Publicado: (2021)

Unraveling structural and conformational dynamics of DGAT1 missense nsSNPs in dairy cattle
por: Pathak, Rajesh Kumar, et al.
Publicado: (2022)

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
por: Dash, Raju, et al.
Publicado: (2022)

Exploration of structural stability in deleterious nsSNPs of the XPA gene: A molecular dynamics approach
por: NagaSundaram, N, et al.
Publicado: (2011)

In Silico Analysis of nsSNPs of Human KRAS Gene and Protein Modeling Using Bioinformatic Tools
por: Xu, Duoduo, et al.
Publicado: (2023)

Accurate Sequence-Based Prediction of Deleterious nsSNPs with Multiple Sequence Profiles and Putative Binding Residues
por: Song, Ruiyang, et al.
Publicado: (2021)

Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders
por: Shah, Abid Ali, et al.
Publicado: (2022)

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia
por: Xie, Li, et al.
Publicado: (2013)

Identification of deleterious nsSNPs in α, μ, π and θ class of GST family and their influence on protein structure
por: Yadav, P., et al.
Publicado: (2014)

Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation
por: Essadssi, Soukaina, et al.
Publicado: (2019)

Computational Biology of BRCA2 in Male Breast Cancer, through Prediction of Probable nsSNPs, and Hit Identification
por: Shinde, Sangita Dattatray, et al.
Publicado: (2022)

Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach
por: George Priya Doss, C, et al.
Publicado: (2013)

Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer
por: Lim, Shu Wen, et al.
Publicado: (2021)

Structure SNP (StSNP): a web server for mapping and modeling nsSNPs on protein structures with linkage to metabolic pathways
por: Uzun, Alper, et al.
Publicado: (2007)

In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract
por: Zhang, Mingzhou, et al.
Publicado: (2020)

Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity
por: Bouafi, Hind, et al.
Publicado: (2019)

Computational and Mass Spectrometry-Based Approach Identify Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) in JMJD6
por: Gong, Tianqi, et al.
Publicado: (2021)

A comprehensive in silico investigation into the nsSNPs of Drd2 gene predicts significant functional consequences in dopamine signaling and pharmacotherapy
por: Lira, Samia Sultana, et al.
Publicado: (2021)

Mutation analysis of pathogenic non-synonymous single nucleotide polymorphisms (nsSNPs) in WFS1 gene through computational approaches
por: Zhao, Jing, et al.
Publicado: (2023)

Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators
por: Kumar, Rupesh, et al.
Publicado: (2023)

Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates
por: Ahmad, Hafiz Ishfaq, et al.
Publicado: (2020)

Predicting the most deleterious missense nsSNPs of the protein isoforms of the human HLA-G gene and in silico evaluation of their structural and functional consequences
por: Emadi, Elaheh, et al.
Publicado: (2020)

Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio‐informatics study
por: Coelho, Catarina, et al.
Publicado: (2019)

In silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis
por: Mondal, Amalesh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l2720d22e8hfoav5kclgrimttj