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The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis

BACKGROUND: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers. METHODS: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane...

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Autores principales: Emadzadeh, Maryam, Mehdizadeh, Atieh, Sharifan, Payam, Khoshakhlagh, Mahdieh, Sahebi, Reza, Sadeghi, Ramin, A. Ferns, Gordon, Ghayour-Mobarhan, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273499/
https://www.ncbi.nlm.nih.gov/pubmed/35866135
http://dx.doi.org/10.18502/ijph.v51i2.8681
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author Emadzadeh, Maryam
Mehdizadeh, Atieh
Sharifan, Payam
Khoshakhlagh, Mahdieh
Sahebi, Reza
Sadeghi, Ramin
A. Ferns, Gordon
Ghayour-Mobarhan, Majid
author_facet Emadzadeh, Maryam
Mehdizadeh, Atieh
Sharifan, Payam
Khoshakhlagh, Mahdieh
Sahebi, Reza
Sadeghi, Ramin
A. Ferns, Gordon
Ghayour-Mobarhan, Majid
author_sort Emadzadeh, Maryam
collection PubMed
description BACKGROUND: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers. METHODS: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane Library as well as Science Direct, and Scopus) were considered for this systematic review, until Jan 2020. All randomized controlled trials were included to evaluate the probable relationship between consumption of vitamin D fortification products and bone biomarkers profile in this review. RESULTS: Among serum bone biomarkers (osteocalcin and telopeptides of type-1 collagen) investigated, only the level of telopeptides of type-1 collagen significantly decreased after fortification of vitamin D in the intervention group. A significant increase in vitamin D was seen in those older than 18 yr old, while the increase in younger children was not statistically significant between intervention and control groups. CONCLUSION: Vitamin D fortification was not associated with a significant improvement in bone mass density (BMD), while it resulted in decreased PTH levels. Vitamin D fortified foods have some benefits on bone health due to increase in the level of vitamin D and IGF-1; and decreasing PTH and CTx levels.
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spelling pubmed-92734992022-07-20 The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis Emadzadeh, Maryam Mehdizadeh, Atieh Sharifan, Payam Khoshakhlagh, Mahdieh Sahebi, Reza Sadeghi, Ramin A. Ferns, Gordon Ghayour-Mobarhan, Majid Iran J Public Health Review Article BACKGROUND: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers. METHODS: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane Library as well as Science Direct, and Scopus) were considered for this systematic review, until Jan 2020. All randomized controlled trials were included to evaluate the probable relationship between consumption of vitamin D fortification products and bone biomarkers profile in this review. RESULTS: Among serum bone biomarkers (osteocalcin and telopeptides of type-1 collagen) investigated, only the level of telopeptides of type-1 collagen significantly decreased after fortification of vitamin D in the intervention group. A significant increase in vitamin D was seen in those older than 18 yr old, while the increase in younger children was not statistically significant between intervention and control groups. CONCLUSION: Vitamin D fortification was not associated with a significant improvement in bone mass density (BMD), while it resulted in decreased PTH levels. Vitamin D fortified foods have some benefits on bone health due to increase in the level of vitamin D and IGF-1; and decreasing PTH and CTx levels. Tehran University of Medical Sciences 2022-02 /pmc/articles/PMC9273499/ /pubmed/35866135 http://dx.doi.org/10.18502/ijph.v51i2.8681 Text en Copyright © 2022 Emadzadeh et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Review Article
Emadzadeh, Maryam
Mehdizadeh, Atieh
Sharifan, Payam
Khoshakhlagh, Mahdieh
Sahebi, Reza
Sadeghi, Ramin
A. Ferns, Gordon
Ghayour-Mobarhan, Majid
The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title_full The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title_fullStr The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title_full_unstemmed The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title_short The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
title_sort effects of vitamin d fortified products on bone biomarkers: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273499/
https://www.ncbi.nlm.nih.gov/pubmed/35866135
http://dx.doi.org/10.18502/ijph.v51i2.8681
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