SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage

Copper-zinc superoxide dismutase (SOD1) has been proposed as one of the causative proteins of amyotrophic lateral sclerosis (ALS). The accumulation of non-native conformers, oligomers, and aggregates of SOD1 in motor neurons is considered responsible for this disease. However, it remains unclear whi...

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Detalles Bibliográficos
Autores principales: Yamazaki, Kosuke, Tahara, Shinya, Ohyama, Takumi, Kuroi, Kunisato, Nakabayashi, Takakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273606/
https://www.ncbi.nlm.nih.gov/pubmed/35817830
http://dx.doi.org/10.1038/s41598-022-15701-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273606/
https://www.ncbi.nlm.nih.gov/pubmed/35817830
http://dx.doi.org/10.1038/s41598-022-15701-w

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