Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts

Single-cell Hi-C analysis of diploid human cells is difficult because of the lack of dense chromosome contact information and the presence of homologous chromosomes with very similar nucleotide sequences. Thus here, we propose a new algorithm to reconstruct the three-dimensional (3D) chromosomal arc...

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Detalles Bibliográficos
Autores principales: Hirata, Yoshito, Oda, Arisa H., Motono, Chie, Shiro, Masanori, Ohta, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273635/
https://www.ncbi.nlm.nih.gov/pubmed/35817790
http://dx.doi.org/10.1038/s41598-022-15038-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273635/
https://www.ncbi.nlm.nih.gov/pubmed/35817790
http://dx.doi.org/10.1038/s41598-022-15038-4

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