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Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts
Single-cell Hi-C analysis of diploid human cells is difficult because of the lack of dense chromosome contact information and the presence of homologous chromosomes with very similar nucleotide sequences. Thus here, we propose a new algorithm to reconstruct the three-dimensional (3D) chromosomal arc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273635/ https://www.ncbi.nlm.nih.gov/pubmed/35817790 http://dx.doi.org/10.1038/s41598-022-15038-4 |